The Journal of Allergy and Clinical Immunology
Volume 119, Issue 4 , Pages 937-943 , April 2007

Successful sublingual immunotherapy with birch pollen has limited effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1

  • Tamar Kinaciyan, MD

      Affiliations

    • From the Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases
    • ,
  • Beatrice Jahn-Schmid, PhD

      Affiliations

    • Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna
    • ,
  • Astrid Radakovics

      Affiliations

    • Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna
    • ,
  • Bettina Zwölfer

      Affiliations

    • Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna
    • ,
  • Claudia Schreiber, MD

      Affiliations

    • From the Department of Dermatology, Division of Immunology, Allergy and Infectious Diseases
    • ,
  • James N. Francis, PhD

      Affiliations

    • Upper Respiratory Medicine, National Heart and Lung Institute, Imperial College, London
    • ,
  • Christof Ebner, MD

      Affiliations

    • Allergy Clinic Reumannplatz, Vienna
    • ,
  • Barbara Bohle, PhD

      Affiliations

    • Department of Pathophysiology, Center for Physiology and Pathophysiology, Medical University of Vienna
    • Corresponding Author InformationReprint requests: Barbara Bohle, PhD, Medical University of Vienna, Center for Physiology and Pathophysiology, Department of Pathophysiology, Waehringer Guertel 18-20, AKH-3Q, A-1090 Wien, Austria.

Received 17 August 2006 ,Revised 2 November 2006 ,Accepted 3 November 2006.

References 

  1. Wuthrich B, Schindler C, Leuenberger P, Ackermann-Liebrich U. Prevalence of atopy and pollinosis in the adult population of Switzerland (SAPALDIA study). Swiss Study on Air Pollution and Lung Diseases in Adults. Int Arch Allergy Immunol. 1995;106:149–156
  2. Eriksson NE. Food sensitivity reported by patients with asthma and hay fever: a relationship between food sensitivity and birch pollen-allergy and between food sensitivity and acetylsalicylic acid intolerance. Allergy. 1978;33:189–196
  3. Dreborg S, Foucard T. Allergy to apple, carrot and potato in children with birch pollen allergy. Allergy. 1983;38:167–172
  4. Ebner C, Birkner T, Valenta R, Rumpold H, Breitenbach M, Scheiner O, et al. Common epitopes of birch pollen and apples: studies by Western and Northern blot. J Allergy Clin Immunol. 1991;88:588–594
  5. Wensing M, Akkerdaas JH, van Leeuwen WA, Stapel SO, Bruijnzeel-Koomen CA, Aalberse RC, et al. IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevance. J Allergy Clin Immunol. 2002;110:435–442
  6. Vanek-Krebitz M, Hoffmann-Sommergruber K, Laimer da Camara Machado M, Susani M, Ebner C, Kraft D, et al. Cloning and sequencing of Mal d 1, the major allergen from apple (Malus domestica), and its immunological relationship to Bet v 1, the major birch pollen allergen. Biochem Biophys Res Commun. 1995;214:538–551
  7. Fritsch R, Bohle B, Vollmann U, Wiedermann U, Jahn-Schmid B, Krebitz M, et al. Bet v 1, the major birch pollen allergen, and Mal d 1, the major apple allergen, cross-react at the level of allergen-specific T helper cells. J Allergy Clin Immunol. 1998;102:679–686
  8. Kazemi-Shirazi L, Pauli G, Purohit A, Spitzauer S, Froschl R, Hoffmann-Sommergruber K, et al. Quantitative IgE inhibition experiments with purified recombinant allergens indicate pollen-derived allergens as the sensitizing agents responsible for many forms of plant food allergy. J Allergy Clin Immunol. 2000;105:116–125
  9. Asero R. Effects of birch pollen-specific immunotherapy on apple allergy in birch pollen-hypersensitive patients. Clin Exp Allergy. 1998;28:1368–1373
  10. Modrzynski M, Zawisza E, Rapiejko P, Przybylski G. [Specific-pollen immunotherapy in the treatment of oral allergy syndrome in patients with tree pollen hypersensitivity]. Przegl Lek. 2002;59:1007–1010
  11. Herrmann D, Henzgen M, Frank E, Rudeschko O, Jager L. Effect of hyposensitization for tree pollinosis on associated apple allergy. J Investig Allergol Clin Immunol. 1995;5:259–267
  12. Bolhaar ST, Tiemessen MM, Zuidmeer L, van Leeuwen A, Hoffmann-Sommergruber K, Bruijnzeel-Koomen CA, et al. Efficacy of birch-pollen immunotherapy on cross-reactive food allergy confirmed by skin tests and double-blind food challenges. Clin Exp Allergy. 2004;34:761–769
  13. Bucher X, Pichler WJ, Dahinden CA, Helbling A. Effect of tree pollen specific, subcutaneous immunotherapy on the oral allergy syndrome to apple and hazelnut. Allergy. 2004;59:1272–1276
  14. Asero R. How long does the effect of birch pollen injection SIT on apple allergy last?. Allergy. 2003;58:435–438
  15. Moller C. Effect of pollen immunotherapy on food hypersensitivity in children with birch pollinosis. Ann Allergy. 1989;62:343–345
  16. Hansen KS, Khinchi MS, Skov PS, Bindslev-Jensen C, Poulsen LK, Malling HJ. Food allergy to apple and specific immunotherapy with birch pollen. Mol Nutr Food Res. 2004;48:441–448
  17. Ortolani C, Ispano M, Pastorello E, Bigi A, Ansaloni R. The oral allergy syndrome. Ann Allergy. 1988;61:47–52
  18. Bousquet J. Sublingual immunotherapy: from proven prevention to putative rapid relief of allergic symptoms. Allergy. 2005;60:1–3
  19. Bousquet J. Sublingual immunotherapy: validated!. Allergy. 2006;61(suppl 81):5–6
  20. Wilson DR, Lima MT, Durham SR. Sublingual immunotherapy for allergic rhinitis: systematic review and meta-analysis. Allergy. 2005;60:4–12
  21. Canonica GW, Passalacqua G. Sublingual immunotherapy in the treatment of adult allergic rhinitis patients. Allergy. 2006;61(suppl 81):20–23
  22. Potter PC. Update on sublingual immunotherapy. Ann Allergy Asthma Immunol. 2006;96:S22–S25
  23. Khinchi MS, Poulsen LK, Carat F, Andre C, Hansen AB, Malling HJ. Clinical efficacy of sublingual and subcutaneous birch pollen allergen-specific immunotherapy: a randomized, placebo-controlled, double-blind, double-dummy study. Allergy. 2004;59:45–53
  24. Marogna M, Spadolini I, Massolo A, Canonica GW, Passalacqua G. Clinical, functional, and immunologic effects of sublingual immunotherapy in birch pollinosis: a 3-year randomized controlled study. J Allergy Clin Immunol. 2005;115:1184–1188
  25. Schimek EM, Zwolfer B, Briza P, Jahn-Schmid B, Vogel L, Vieths S, et al. Gastrointestinal digestion of Bet v 1-homologous food allergens destroys their mediator-releasing, but not T cell-activating, capacity. J Allergy Clin Immunol. 2005;116:1327–1333
  26. Jahn-Schmid B, Radakovics A, Luttkopf D, Scheurer S, Vieths S, Ebner C, et al. Bet v 1142-156 is the dominant T-cell epitope of the major birch pollen allergen and important for cross-reactivity with Bet v 1-related food allergens. J Allergy Clin Immunol. 2005;116:213–219
  27. Bohle B, Zwolfer B, Heratizadeh A, Jahn-Schmid B, Antonia YD, Alter M, et al. Cooking birch pollen-related food: divergent consequences for IgE- and T cell-mediated reactivity in vitro and in vivo. J Allergy Clin Immunol. 2006;118:242–249
  28. Asero R. Effects of birch pollen SIT on apple allergy: a matter of dosage?. Allergy. 2004;59:1269–1271
  29. Fanta C, Bohle B, Hirt W, Siemann U, Horak F, Kraft D, et al. Systemic immunological changes induced by administration of grass pollen allergens via the oral mucosa during sublingual immunotherapy. Int Arch Allergy Immunol. 1999;120:218–224
  30. Cosmi L, Santarlasci V, Angeli R, Liotta F, Maggi L, Frosali F, et al. Sublingual immunotherapy with Dermatophagoides monomeric allergoid down-regulates allergen-specific immunoglobulin E and increases both interferon-gamma- and interleukin-10-production. Clin Exp Allergy. 2006;36:261–272
  31. Bagnasco M, Mariani G, Passalacqua G, Motta C, Bartolomei M, Falagiani P, et al. Absorption and distribution kinetics of the major Parietaria judaica allergen (Par j 1) administered by noninjectable routes in healthy human beings. J Allergy Clin Immunol. 1997;100:122–129
  32. Bohle B, Radakovics A, Jahn-Schmid B, Hoffmann-Sommergruber K, Fischer GF, Ebner C. Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level. Eur J Immunol. 2003;33:3303–3310
  33. Bohle B, Radakovics A, Luttkopf D, Jahn-Schmid B, Vieths S, Ebner C. Characterization of the T cell response to the major hazelnut allergen, Cor a 1.04: evidence for a relevant T cell epitope not cross-reactive with homologous pollen allergens. Clin Exp Allergy. 2005;35:1392–1399

 Supported by the Fonds zur Förderung der wissenschaftlichen Forschung (SFB-F1807-B04), Austria.Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(06)02355-4

doi: 10.1016/j.jaci.2006.11.010

The Journal of Allergy and Clinical Immunology
Volume 119, Issue 4 , Pages 937-943 , April 2007

Article Tools

* Image Usage & Resolution