The Journal of Allergy and Clinical Immunology
Volume 119, Issue 1 , Pages 206-212 , January 2007

Esophageal remodeling in pediatric eosinophilic esophagitis

  • Seema S. Aceves, MD, PhD

      Affiliations

    • From the Divisions of Allergy, Immunology
    • Pediatrics
    • Corresponding Author InformationReprint requests: Seema S. Aceves, MD, PhD, Division of Allergy, Immunology, MC-5114, Children's Hospital, San Diego, 3020 Children's Way, San Diego, CA 92123.
  • ,
  • Robert O. Newbury, MD

      Affiliations

    • Pathology
  • ,
  • Ranjan Dohil, MD

      Affiliations

    • Pediatrics
    • Gastroenterology
  • ,
  • John F. Bastian, MD

      Affiliations

    • From the Divisions of Allergy, Immunology
    • Pediatrics
  • ,
  • David H. Broide, MBChB

      Affiliations

    • From the Divisions of Allergy, Immunology
    • Medicine, Children's Hospital, San Diego, and the University of California, San Diego

Received 15 June 2006 ,Revised 5 October 2006 ,Accepted 10 October 2006.

References 

  1. Noel RJ, Putnam PE, Rothenberg ME. Eosinophilic esophagitis. N Engl J Med. 2004;351:940–941
  2. Straumann A, Simon HU. Eosinophilic esophagitis: escalating epidemiology?. J Allergy Clin Immunol. 2005;115:418–419
  3. Aceves SA, Newbury R, Dohil R, Schwimmer J, Bastian JF. Distinguishing eosinophilic esophagitis in pediatric patients: clinical, endoscopic, and histologic features of an emerging disorder. J Clin Gastroenterol 2007. In press.
  4. Orenstein SR, Shalaby TM, DiLorenzo C, Kocoshis SA, Putnam PE, Sigurdsson L, et al. The spectrum of pediatric eosinophilic esophagitis beyond infancy: a clinical series of 30 patients. Am J Gastroenterol. 2000;95:1422–1430
  5. Rothenberg ME, Mishra A, Collins MH, Putnam PE. Pathogenesis and clinical features of eosinophilic esophagitis. J Allergy Clin Immunol. 2001;108:891–894
  6. Rothenberg ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol. 2004;113:11–28
  7. Parfitt JR, Gregor JC, Suskin NG, Jawa HA, Driman DK. Eosinophilic esophagitis in adults: distinguishing features from gastroesophageal reflux disease: a study of 41 patients. Mod Pathol. 2006;19:90–96
  8. Ruchelli E, Wenner W, Voytek T, Brown K, Liacouras C. Severity of esophageal eosinophilia predicts response to conventional gastroesophageal reflux therapy. Pediatr Dev Pathol. 1999;2:15–18
  9. Liacouras CA, Spergel JM, Ruchelli E, Verma R, Mascarenhas M, Semeao E, et al. Eosinophilic esophagitis: a 10-year experience in 381 children. Clin Gastroenterol Hepatol. 2005;3:1198–1206
  10. Fox VL, Nurko S, Teitelbaum JE, Badizadegan K, Furuta GT. High-resolution EUS in children with eosinophilic “allergic” esophagitis. Gastrointest Endosc. 2003;57:30–36
  11. Straumann A, Spichtin HP, Bucher KA, Heer P, Simon HU. Eosinophilic esophagitis: red on microscopy, white on endoscopy. Digestion. 2004;70:109–116
  12. Desai TK, Stecevic V, Chang CH, Goldstein NS, Badizadegan K, Furuta GT. Association of eosinophilic inflammation with esophageal food impaction in adults. Gastrointest Endosc. 2005;61:802–803
  13. Khan S, Orenstein SR, Di Lorenzo C, Kocoshis SA, Putnam PE, Sigurdsson L, et al. Eosinophilic esophagitis: strictures, impactions, dysphagia. Dig Dis Sci. 2003;48:22–29
  14. Mishra A, Hogan SP, Brandt EB, Rothenberg ME. An etiologic role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest. 2001;107:83–90
  15. Fogg MJ, Ruchelli E, Spergel JM. Pollen and eosinophilic esophagitis. J Allergy Clin Immunol. 2003;112:796–797
  16. Markowitz JE, Spergel JM, Ruchelli E, Liacouras CA. Elemental diet is an effective treatment for eosinophilic esophagitis in children and adolescents. Am J Gastroenterol. 2003;98:777–782
  17. Spergel JM, Andrews T, Brown-Whitehorn TF, Beausoleil JL, Liacouras CA. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol. 2005;95:336–343
  18. Liacouras CA, Ruchelli E. Eosinophilic esophagitis. Curr Opin Pediatr. 2004;15:560–566
  19. Guajardo JR, Plotnick LM, Fende JM, Collins MH, Putnam PE, Rothenberg ME. Eosinophil-associated gastrointestinal disorders: a world-wide-web based registry. J Pediatr. 2002;141:576–581
  20. Straumann A, Spichtin HP, Grize L, Bucher KA, Beglinger C, Simon HU. Natural history of primary eosinophilic esophagitis: a follow-up of 30 adult patients for up to 11.5 years. Gastroenterology. 2003;125:1660–1669
  21. Straumann A, Kristl J, Conus S, Vassina E, Spichtin HP, Beglinger C, et al. Cytokine expression in healthy and inflamed mucosa: probing the role of eosinophils in the digestive tract. Inflamm Bowel Dis. 2005;11:720–726
  22. Gupta SK, Fitzgerald JF, Kondratyuk T, HogenEsch H. Cytokine expression in normal and inflamed esophageal mucosa: a study into the pathogenesis of allergic eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2006;4:22–26
  23. Straumann A, Bauer M, Fischer B, Blaser K, Simon HU. Idiopathic eosinophilic esophagitis is associated with a Th2-type allergic inflammatory response. J Allergy Clin Immunol. 2001;108:954–961
  24. Blanchard C, Wang N, Stringer KF, Mishra A, Fulkerson PC, Abonia JP, et al. Eotaxin-3 and a uniquely conserved gene expression profile in eosinophilic esophagitis. J Clin Invest. 2006;116:536–547
  25. Blanchard E, Mishra A, Saito-Akei H, Monk P, Anderson I, Rothenberg ME. Inhibition of human interleukin-13-induced respiratory and oesophageal inflammation by anti-human-interleukin-13 antibody (CAT-354). Clin Exp Allergy. 2005;35:1096–1103
  26. Mishra A, Rothenberg ME. Intratracheal IL-13 induces eosinophilic esophagitis by an IL-5, eotaxin-1, and STAT6-dependent mechanism. Gastroenterology. 2003;125:1419–1427
  27. Mishra A, Hogan SP, Brandt EB, Rothenberg ME. IL-5 promotes eosinophil trafficking to the esophagus. J Immunol. 2002;168:2464–2469
  28. Garrett JK, Jameson SC, Thomson B, Collins MH, Wagoner LE, Freese DK, et al. Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. J Allergy Clin Immunol. 2004;113:115–119
  29. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Lee SY, et al. Immunostimulatory DNA inhibits transforming growth factor-beta expression and airway remodeling. Am J Respir Cell Mol Biol. 2004;30:651–661
  30. Cho JY, Miller M, Baek KJ, Han JW, Nayar J, Lee SY, et al. Inhibition of airway remodeling in IL-5-deficient mice. J Clin Invest. 2004;113:551–560
  31. Flood-Page P, Menzies-Gow A, Phipps S, Ying S, Wangoo A, Ludwig MS, et al. Anti-IL-5 treatment reduces deposition of ECM proteins in the bronchial subepithelial basement membrane of mild atopic asthmatics. J Clin Invest. 2003;112:1029–1036
  32. McMillan SJ, Xanthou G, Lloyd CM. Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-beta antibody: effect on the Smad signaling pathway. J Immunol. 2005;174:5774–5780
  33. Zhao J, Shi W, Wang YL, Chen H, Bringas P, Datto MB, et al. Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice. Am J Physiol Lung Cell Mol Physiol. 2002;3:L585–L593
  34. Steiner SJ, Kernek KM, Fitzgerald JF. Severity of basal cell hyperplasia differs in reflux versus eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2006;42:506–509
  35. Chehade M, Sampson HA, Magid MS. Esophageal fibrosis in children with allergic eosinophilic esophagitis. [abstract] J Allergy Clin Immunol. 2006;117:S304
  36. Broide DH, Stachnick G, Castaneda D, Nayar J, Sriramarao P. Inhibition of eosinophilic inflammation in allergen-challenged TNF receptor p55/p75- and TNF receptor p55-deficient mice. Am J Respir Cell Mol Biol. 2001;24:304–311

 Supported by the American Academy of Allergy, Asthma & Immunology Education and Research Trust (ERT) Clinical Research Grant (S.S.A.), National Institutes of Health T32 Training award AI 007469 (S.S.A.), and National Institutes of Health grant AI 38425 (D.H.B.).Disclosure of potential conflict of interest: S. S. Aceves has received grant support from the American Academy of Allergy, Asthma and Immunology Clinical ERT. D. H. Broide has received grant support from the National Institutes of Health. The other authors have declared that they have no conflict of interest.

PII: S0091-6749(06)02136-1

doi: 10.1016/j.jaci.2006.10.016

The Journal of Allergy and Clinical Immunology
Volume 119, Issue 1 , Pages 206-212 , January 2007