The Journal of Allergy and Clinical Immunology
Volume 119, Issue 1 , Pages 184-191 , January 2007

Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: A randomized controlled trial

  • Angie L. Taylor, BSc Hons
    • ,
  • Janet A. Dunstan, BAplSc, PhD
    • ,
  • Susan L. Prescott, MBBS, PhD, FRACP

      Affiliations

    • Corresponding Author InformationReprint requests: Susan L. Prescott, MBBS, PhD, FRACP, School of Paediatrics and Child Health, University of Western Australia, PO Box D184, Princess Margaret Hospital, Perth WA 6001, Australia.

Received 31 May 2006 ,Revised 25 August 2006 ,Accepted 29 August 2006.

  • Image Result

    Flow chart showing progress of participants through the trial.

    Flow chart showing progress of participants through the trial.

  • Image Result

    Odds ratios (and 95% CIs) of infants in the probiotic group developing early symptoms of allergic disease or sensitization (SPT-positive) at 1 year of age compared with the placebo group.

    Odds ratios (and 95% CIs) of infants in the probiotic group developing early symptoms of allergic disease or sensitization (SPT-positive) at 1 year of age compared with the placebo group.

 Supported jointly by the National Health and Medical Research Council of Australia and Probiomics as an industry partner. The study and all of the analyses were conducted independently of the commercial entity.Disclosure of potential conflict of interest: A. L. Taylor, J. A. Dunstan, and S. L. Prescott have received grant support from the National Health and Medical Research Council of Australia and Probiomics.

PII: S0091-6749(06)01798-2

doi: 10.1016/j.jaci.2006.08.036

The Journal of Allergy and Clinical Immunology
Volume 119, Issue 1 , Pages 184-191 , January 2007

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