The Journal of Allergy and Clinical Immunology
Volume 118, Issue 6 , Pages 1271-1278 , December 2006

Influence of dog ownership and high endotoxin on wheezing and atopy during infancy

  • Paloma Campo, MD

      Affiliations

    • Department of Internal Medicine, Immunology Division
    • These authors contributed equally to this work.
    • ,
  • Harpinder K. Kalra, MD

      Affiliations

    • Department of Internal Medicine, Immunology Division
    • These authors contributed equally to this work.
    • ,
  • Linda Levin, PhD

      Affiliations

    • Department of Environmental Health, University of Cincinnati
    • ,
  • Tiina Reponen, PhD

      Affiliations

    • Department of Environmental Health, University of Cincinnati
    • ,
  • Rolanda Olds, BS

      Affiliations

    • Department of Internal Medicine, Immunology Division
    • ,
  • Zana L. Lummus, PhD

      Affiliations

    • Department of Internal Medicine, Immunology Division
    • ,
  • Seung-Hyun Cho, PhD

      Affiliations

    • Department of Environmental Health, University of Cincinnati
    • ,
  • Gurjit K. Khurana Hershey, MD, PhD

      Affiliations

    • Division of Allergy and Immunology, Children's Hospital Medical Center
    • ,
  • James Lockey, MD

      Affiliations

    • Department of Environmental Health, University of Cincinnati
    • ,
  • Manuel Villareal, MD

      Affiliations

    • Department of Internal Medicine, Immunology Division
    • ,
  • Sherry Stanforth, CNP

      Affiliations

    • Department of Internal Medicine, Immunology Division
    • ,
  • Grace LeMasters, PhD

      Affiliations

    • Department of Environmental Health, University of Cincinnati
    • ,
  • David I. Bernstein, MD

      Affiliations

    • Department of Internal Medicine, Immunology Division
    • Corresponding Author InformationReprint requests: David I. Bernstein, MD, University of Cincinnati, PO Box 670563, Cincinnati, OH 45267-0563.

Received 23 November 2005 ,Revised 27 July 2006 ,Accepted 1 August 2006.

  • Image Result

    GM of endotoxin levels (EU/mg) in settled dust according to number of dogs present in the home (n = 532; Spearman P = .003).

    GM of endotoxin levels (EU/mg) in settled dust according to number of dogs present in the home (n = 532; Spearman P = .003).

  • Image Result

    Smoothed plots of the adjusted prevalence rates of recurrent wheeze (A) and recurrent wheeze with an event (B) in relation to endotoxin concentration plotted on a logarithmic scale (solid lines). Dott

    Smoothed plots of the adjusted prevalence rates of recurrent wheeze (A) and recurrent wheeze with an event (B) in relation to endotoxin concentration plotted on a logarithmic scale (solid lines). Dotted lines represent ±1 SE.

  • Image Result
    Prevalence of positive SPTs to aeroallergens among infants (n = 532) in households with pets (dog/cat), no pets, dog only, cat only, and number of dogs at home. No significant differences were found b

    Prevalence of positive SPTs to aeroallergens among infants (n = 532) in households with pets (dog/cat), no pets, dog only, cat only, and number of dogs at home. No significant differences were found between homes with pets and without pets.

 Supported by National Institute of Environmental Health Sciences grant NIEHS 1-RO1-ES11170-04 and a Fondo de Investigacion Sanitaria (FIS)/Fulbright Scholarship awarded to Paloma Campo.Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(06)01708-8

doi: 10.1016/j.jaci.2006.08.008

The Journal of Allergy and Clinical Immunology
Volume 118, Issue 6 , Pages 1271-1278 , December 2006

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