« Previous Next » The Journal of Allergy and Clinical Immunology
Volume 118, Issue 5 , Pages 1075-1081 , November 2006

Small airways response to naturalistic cat allergen exposure in subjects with asthma

Michelle R. Zeidler, MD, MS
- From the Divisions of Pulmonary, Critical Care Medicine and Hospitalists
Jonathan G. Goldin, MD, PhD
- Thoracic Radiology, David Geffen School of Medicine
Eric C. Kleerup, MD
- From the Divisions of Pulmonary, Critical Care Medicine and Hospitalists
Hyun J. Kim, MS
- Thoracic Radiology, David Geffen School of Medicine
Dao A. Truong, BS
- Thoracic Radiology, David Geffen School of Medicine
David W. Gjertson, PhD
- Thoracic Radiology, David Geffen School of Medicine
Nola J. Kennedy, PhD
- School of Public Health, University of California, Los Angeles
Kenneth B. Newman, MD
- Forest Laboratories, New York
Donald P. Tashkin, MD
- From the Divisions of Pulmonary, Critical Care Medicine and Hospitalists
Jeffrey M. Silverman, MD
- Keck School of Medicine at the University of Southern California and Landmark Imaging
Jonathan Corren, MD
- Division of Clinical Immunology and Allergy, David Geffen School of Medicine and Allergy Research Foundation
- Reprint requests: Jonathan Corren, MD, Allergy Research Foundation, 11620 Wilshire Blvd, Suite 200, Los Angeles, CA 90025.

Received 24 April 2006 ,Revised 21 June 2006 ,Accepted 22 June 2006.

Study timeline. PFT, Pulmonary function test, including CV.

Study timeline. PFT, Pulmonary function test, including CV.
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HRCT data analysis. A, The acquisition of 12 regions of interest consisting of right rostral, right caudal, left rostral, and left caudal, each subdivided into ventral (nondependent), intermediate, an

HRCT data analysis. A, The acquisition of 12 regions of interest consisting of right rostral, right caudal, left rostral, and left caudal, each subdivided into ventral (nondependent), intermediate, and dorsal (dependent) sections. A lung attenuation curve is then derived for each regions of interest. B, A representative lung attenuation curve. Reproduced with permission from Zeidler MR, Goldin J, Kleerup EC, Truong D, Simmons M, Kim HJ, et al. Montelukast improves regional air-trapping due to small airways obstruction in asthma. Eur Respir J 2006;27:307-15.¹⁵
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Time course of changes in FEF25-75 (A) and FEV1 (B) at baseline, CRC, and recovery.

Time course of changes in FEF_25-75 (A) and FEV₁ (B) at baseline, CRC, and recovery.
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Representative lung attenuation curves at baseline and 6 hours and 23 hours after CRC.

Representative lung attenuation curves at baseline and 6 hours and 23 hours after CRC.
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Representative images at PM baseline (A), AM baseline (B), and 6 (C) and 23 hours (D) after CRC.

Representative images at PM baseline (A), AM baseline (B), and 6 (C) and 23 hours (D) after CRC.
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Supported by Forest Pharmaceuticals.Disclosure of potential conflict of interest: E. C. Kleerup has received grant support from Forest; K. B. Newman is employed by Forest Labs; D. P. Tashkin has consultant arrangements with IVAX Pharmaceuticals, has received grant support from Merck and IVAX Pharmaceuticals, and is on the speakers bureau for IVAX Pharmaceuticals; J. Corren has received grant support from SPRI, AstraZeneca, Sepracor, GlaxoSmithKline, and Sky Pharma and is on the speakers bureau for SPRI and Sepracor. The rest of the authors have declared they have no conflict of interest.

PII: S0091-6749(06)01577-6

doi: 10.1016/j.jaci.2006.06.042

« Previous Next » The Journal of Allergy and Clinical Immunology
Volume 118, Issue 5 , Pages 1075-1081 , November 2006