The Journal of Allergy and Clinical Immunology
Volume 118, Issue 1 , Pages 257-268 , July 2006

Resistin-like molecule β regulates innate colonic function: Barrier integrity and inflammation susceptibility

  • Simon P. Hogan, PhD

      Affiliations

    • From the Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
    • These authors contributed equally to this work.
    • ,
  • Luqman Seidu, MD

      Affiliations

    • From the Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
    • These authors contributed equally to this work.
    • ,
  • Carine Blanchard, PhD

      Affiliations

    • From the Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
    • ,
  • Katherine Groschwitz, BS

      Affiliations

    • Department of Immunobiology, University of Cincinnati College of Medicine
    • ,
  • Anil Mishra, PhD

      Affiliations

    • From the Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
    • ,
  • Margaret L. Karow, PhD

      Affiliations

    • Regeneron Pharmaceuticals, Inc, Tarrytown, NY
    • ,
  • Richard Ahrens, BS

      Affiliations

    • From the Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
    • ,
  • David Artis, PhD

      Affiliations

    • Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia
    • ,
  • Andrew J. Murphy, PhD

      Affiliations

    • Regeneron Pharmaceuticals, Inc, Tarrytown, NY
    • ,
  • David M. Valenzuela, PhD

      Affiliations

    • Regeneron Pharmaceuticals, Inc, Tarrytown, NY
    • ,
  • George D. Yancopoulos, MD, PhD

      Affiliations

    • Regeneron Pharmaceuticals, Inc, Tarrytown, NY
    • ,
  • Marc E. Rothenberg, MD, PhD

      Affiliations

    • From the Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine
    • Corresponding Author InformationReprint requests: Marc E. Rothenberg, MD, PhD, Division of Allergy and Immunology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, ML7028, Cincinnati OH 45229.

Received 16 March 2006 ,Revised 7 April 2006 ,Accepted 10 April 2006.

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 Supported in part by the DDRDC Pilot and Feasibility Grant (NIH R24 DK64403; S.P.H.), R01 AI42242 (M.E.R.), AI45898 (M.E.R.), AI53479 (M.E.R.), and the Burroughs Wellcome Fund (M.E.R.) RO1 AI61570 (D.A.) and the Crohn's and Colitis Foundation of America's William and Shelby Modell Family Foundation Research Award (D.A.), and T32 AI060515 (L.S.).Disclosure of potential conflict of interest: A. Mishra has received grant support from the National Institutes of Health. A. J. Murphy owns stock in and is employed by Regeneron Pharmaceuticals, Inc. M. E. Rothenberg owns stock in Ception Therapeutics, is the inventor of a patent application filed by CCHMC concerning RELM-β, has received grant support from Cambridge Antibody Technology, and is on the speakers' bureau for Merck. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(06)00932-8

doi: 10.1016/j.jaci.2006.04.039

The Journal of Allergy and Clinical Immunology
Volume 118, Issue 1 , Pages 257-268 , July 2006

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