The Journal of Allergy and Clinical Immunology
Volume 118, Issue 1 , Pages 53-61 , July 2006

Prevention of asthma during the first 5 years of life: A randomized controlled trial

  • Guy B. Marks, PhD

      Affiliations

    • From the Woolcock Institute of Medical Research
    • University of Sydney
    • Cooperative Research Centre for Asthma
    • Corresponding Author InformationReprint requests: Guy B. Marks, PhD, Woolcock Institute of Medical Research, PO Box M77, Missenden Road Post Office, New South Wales 2050, Australia.
  • ,
  • Seema Mihrshahi, MPH

      Affiliations

    • Children's Hospital at Westmead
  • ,
  • Andrew S. Kemp, PhD

      Affiliations

    • University of Sydney
    • Children's Hospital at Westmead
  • ,
  • Euan R. Tovey, PhD

      Affiliations

    • From the Woolcock Institute of Medical Research
    • University of Sydney
  • ,
  • Karen Webb, PhD

      Affiliations

    • University of Sydney
  • ,
  • Catarina Almqvist, PhD

      Affiliations

    • From the Woolcock Institute of Medical Research
    • University of Sydney
    • Cooperative Research Centre for Asthma
  • ,
  • Rosario D. Ampon, MAppStat

      Affiliations

    • From the Woolcock Institute of Medical Research
  • ,
  • Daniel Crisafulli, BSc

      Affiliations

    • From the Woolcock Institute of Medical Research
    • Cooperative Research Centre for Asthma
  • ,
  • Elena G. Belousova, MSc(AppMath)

      Affiliations

    • From the Woolcock Institute of Medical Research
    • Cooperative Research Centre for Asthma
  • ,
  • Craig M. Mellis, MD

      Affiliations

    • University of Sydney
    • Children's Hospital at Westmead
  • ,
  • Jennifer K. Peat, PhD

      Affiliations

    • Children's Hospital at Westmead
  • ,
  • Stephen R. Leeder, PhD

      Affiliations

    • University of Sydney
  • ,
  • for the Childhood Asthma Prevention Study team

Received 30 November 2005 ,Revised 3 April 2006 ,Accepted 4 April 2006.

References 

  1. Burney P, Chinn S, Rona R. Has the prevalence of asthma increased in children? evidence from the national study of health and growth 1973-86. BMJ. 1990;300:1306–1310
  2. Peat JK, van den Berg RH, Green WF, Mellis CM, Leeder SR, Woolcock AJ. Changing prevalence of asthma in Australian children. BMJ. 1994;308:1591–1596
  3. Waite DA, Eyles EF, Tonkin SL, O'Donnell TV. Asthma prevalence in Tokelauan children in two environments. Clin Allergy. 1980;10:71–75
  4. von Mutius E, Martinez F, Fritzsch C, Nicolai T, Roell G, Thiemann HH. Prevalence of asthma and atopy in two areas of West and East Germany. Am J Respir Crit Care Med. 1994;149:358–364
  5. Jenkins M, Hopper J, Bowes G, Carlin J, Flander L, Giles G. Factors in childhood as predictors of asthma in adult life. BMJ. 1994;309:90–93
  6. Platts-Mills T, de Weck A. Dust mite allergens and asthma: a worldwide problem. J Allergy Clin Immunol. 1989;83:416–427
  7. Peat J, Woolcock A. Sensitivity to common allergens: relation to respiratory symptoms and bronchial hyper-responsiveness in children from three different climatic areas of Australia. Clin Exp Allergy. 1991;21:573–581
  8. Korsgaard J. Mite asthma and residency: a case-control study on the impact of exposure to house-dust mites in dwellings. Am Rev Respir Dis. 1983;128:231–235
  9. Sporik R, Holgate S, Platts-Mills T, Cogswell J. Exposure to house-dust mite allergen (Der p I) and the development of asthma in childhood: a prospective study. N Engl J Med. 1990;323:502–507
  10. Hodge L, Salome C, Peat J, Haby M, Xuan W, Woolcock A. Consumption of oily fish and childhood asthma risk. Med J Aust. 1996;164:137–140
  11. Haby M, Peat J, Marks G, Woolcock A, Leeder S. Asthma in pre-school children: prevalence and risk factors. Thorax. 2001;56:589–595
  12. Platts-Mills T, Vervolet D, Thomas W, Aalberse R, Chapman M. Indoor allergens and asthma. Third International Workshop, Cuenca. Spain. J Allergy Clin Immunol. 1997;100:S1–S24
  13. Mihrshahi S, Peat J, Webb K, Tovey E, Marks G, Mellis C, et al. The Childhood Asthma Prevention Study (CAPS): design and research protocol of a large randomised trial of the primary prevention of asthma. Control Clin Trials. 2001;22:333–354
  14. Mihrshahi S, Peat J, Marks G, Mellis C, Tovey E, Webb K, et al. Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the childhood asthma prevention study (CAPS). J Allergy Clin Immunol. 2003;111:162–168
  15. Peat JK, Mihrshahi S, Kemp AS, Marks GB, Tovey ER, Webb K, et al. Three year outcomes of dietary fatty acid modification and house dust mite reduction in the Childhood Asthma Prevention Study (CAPS). J Allergy Clin Immunol. 2004;114:807–813
  16. International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee . Worldwide variation in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and atopic eczema: ISAAC. Lancet. 1998;351:1225–1232
  17. Williams H, Robertson C, Stewart A, Ait-Khaled N, Anabwani G, Anderson R, et al. Worldwide variations in the prevalence of symptoms of atopic eczema in the international study of asthma and allergies in childhood. J Allergy Clin Immunol. 1999;103:125–138
  18. Mihrshahi S, Marks GB, Criss S, Tovey ER, Vanlaar CH, Peat JK. Effectiveness of an intervention to reduce house dust mite allergen levels in children's beds. Allergy. 2003;58:784–789
  19. Warner J, Naspitz C, Cropp G. Third international pediatric consensus statement on the management of childhood asthma. Pediatr Pulmonol. 1998;25:1–17
  20. Williams H, Burney P, Hay R, Archer C, Shipley M, Hunter J, et al. The U.K. Working Party's diagnostic criteria for atopic dermatitis, I: derivation of a minimum set of discriminators for atopic dermatitis. Br J Dermatol. 1994;131:383–396
  21. Mihrshahi S, Vukasin N, Forbes S, Wainwright C, Krause W, Ampon R, et al. Are you busy for the next five years? recruitment in the Childhood Asthma Prevention Study (CAPS). Respirology. 2002;7:147–151
  22. Chan-Yeung M, Ferguson A, Watson W, Dimich-Ward H, Rousseau R, Lilley M, et al. The Canadian Childhood Asthma Primary Prevention Study: outcomes at 7 years of age. J Allergy Clin Immunol. 2005;116:49–55
  23. Arshad SH, Bateman B, Matthews SM. Primary prevention of asthma and atopy during childhood by allergen avoidance in infancy: a randomised controlled study. Thorax. 2003;58:489–493
  24. Woodcock A, Lowe LA, Murray CS, Simpson BM, Pipis SD, Kissen P, et al. Early life environmental control: effect on symptoms, sensitization, and lung function at age 3 years. Am J Respir Crit Care Med. 2004;170:433–439
  25. Horak F, Matthews S, Ihorst G, Arshad SH, Frischer T, Kuehr J, et al. Effect of mite-impermeable mattress encasings and an educational package on the development of allergies in a multinational randomized, controlled birth-cohort study - 24 months results of the Study of Prevention of Allergy in Children in Europe. Clin Exp Allergy. 2004;34:1220–1225
  26. Koopman LP, van Strien RT, Kerkhof M, Wijga A, Smit HA, de Jongste JC, et al. Placebo-controlled trial of house dust mite-impermeable mattress covers: effect on symptoms in early childhood. Am J Respir Crit Care Med. 2002;166:307–313
  27. Toelle BG, Peat JK, Salome CM, Mellis CM, Woolcock AJ. Toward a definition of asthma for epidemiology. Am Rev Respir Dis. 1992;146:633–637
  28. Dunstan JA, Mori TA, Barden A, Beilin LJ, Taylor AL, Holt PG, et al. Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Immunol. 2003;112:1178–1184
  29. Wahn U, Lau S, Bergmann R, Kulig M, Forster J, Bergmann K, et al. Indoor allergen exposure is a risk factor for sensitization during the first three years of life. J Allergy Clin Immunol. 1997;99:763–769
  30. van Strien RT, Koopman LP, Kerkhof M, Oldenwening M, de Jongste JC, Gerritsen J, et al. Mattress encasings and mite allergen levels in the Prevention and Incidence of Asthma and Mite Allergy study. Clin Exp Allergy. 2003;33:490–495
  31. Custovic A, Simpson B, Simpson A, Hallam C, Craven M, Brutsche M, et al. Manchester Asthma and Allergy Study: low allergen environment can be achieved and maintained during pregnancy and early life. J Allergy Clin Immunol. 2000;105:252–258
  32. Tovey ER, Mitakakis TZ, Sercombe JK, Vanlaar CH, Marks GB. Four methods of sampling for dust mite allergen: differences in “dust. Allergy. 2003;58:790–794
  33. Tovey ER, O'Meara T, Marks G. Bed covers and dust mites. [letter] N Engl J Med. 2003;349:1668–1671
  34. Gehring U, Bolte G, Borte M, Bischof W, Fahlbusch B, Wichmann HE, et al. Exposure to endotoxin decreases the risk of atopic eczema in infancy: a cohort study. J Allergy Clin Immunol. 2001;108:847–854
  35. Meneghini CL, Vena GA, Angelini G. Contact dermatitis to scabicides. Contact Dermatitis. 1982;8:285–286

 Supported by National Health and Medical Research Council of Australia, Cooperative Research Centre for Asthma, New South Wales Department of Health, Children's Hospital Westmead. Dr Almqvist was funded by the Swedish Heart Lung Foundation and Swedish Society of Medicine. Contributions of goods and services were made by Allergopharma Joachim Ganzer KG Germany, John Sands Australia, Hasbro, Toll Refrigerated, AstraZeneca Australia, and Nu-Mega Ingredients Pty Ltd. Goods were provided at reduced cost by Auspharm, Allersearch, and Goodman Fielder Foods.Disclosure of potential conflict of interest: C. M. Mellis has consultant arrangements with Merck Sharp & Dohme, Altana Pharma. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(06)00853-0

doi: 10.1016/j.jaci.2006.04.004

The Journal of Allergy and Clinical Immunology
Volume 118, Issue 1 , Pages 53-61 , July 2006