The Journal of Allergy and Clinical Immunology
Volume 118, Issue 1 , Pages 53-61 , July 2006

Prevention of asthma during the first 5 years of life: A randomized controlled trial

  • Guy B. Marks, PhD

      Affiliations

    • From the Woolcock Institute of Medical Research
    • University of Sydney
    • Cooperative Research Centre for Asthma
    • Corresponding Author InformationReprint requests: Guy B. Marks, PhD, Woolcock Institute of Medical Research, PO Box M77, Missenden Road Post Office, New South Wales 2050, Australia.
    • ,
  • Seema Mihrshahi, MPH

      Affiliations

    • Children's Hospital at Westmead
    • ,
  • Andrew S. Kemp, PhD

      Affiliations

    • University of Sydney
    • Children's Hospital at Westmead
    • ,
  • Euan R. Tovey, PhD

      Affiliations

    • From the Woolcock Institute of Medical Research
    • University of Sydney
    • ,
  • Karen Webb, PhD

      Affiliations

    • University of Sydney
    • ,
  • Catarina Almqvist, PhD

      Affiliations

    • From the Woolcock Institute of Medical Research
    • University of Sydney
    • Cooperative Research Centre for Asthma
    • ,
  • Rosario D. Ampon, MAppStat

      Affiliations

    • From the Woolcock Institute of Medical Research
    • ,
  • Daniel Crisafulli, BSc

      Affiliations

    • From the Woolcock Institute of Medical Research
    • Cooperative Research Centre for Asthma
    • ,
  • Elena G. Belousova, MSc(AppMath)

      Affiliations

    • From the Woolcock Institute of Medical Research
    • Cooperative Research Centre for Asthma
    • ,
  • Craig M. Mellis, MD

      Affiliations

    • University of Sydney
    • Children's Hospital at Westmead
    • ,
  • Jennifer K. Peat, PhD

      Affiliations

    • Children's Hospital at Westmead
    • ,
  • Stephen R. Leeder, PhD

      Affiliations

    • University of Sydney
    • ,
  • for the Childhood Asthma Prevention Study team

Received 30 November 2005 ,Revised 3 April 2006 ,Accepted 4 April 2006.

  • Image Result

    HDM allergen concentrations in fine dust collected from children's beds throughout the study period in the active and control HDM intervention groups. Geometric means and 95% CIs are shown.

    HDM allergen concentrations in fine dust collected from children's beds throughout the study period in the active and control HDM intervention groups. Geometric means and 95% CIs are shown.

  • Image Result

    Proportion of ω-3 and ω-6 plasma fatty acids at ages 18 months, 3 years, and 5 years among participants followed up at 5 years. Medians and interquartile ranges are shown. All differences active vs co

    Proportion of ω-3 and ω-6 plasma fatty acids at ages 18 months, 3 years, and 5 years among participants followed up at 5 years. Medians and interquartile ranges are shown. All differences active vs control are significant, P < .0001.

 Supported by National Health and Medical Research Council of Australia, Cooperative Research Centre for Asthma, New South Wales Department of Health, Children's Hospital Westmead. Dr Almqvist was funded by the Swedish Heart Lung Foundation and Swedish Society of Medicine. Contributions of goods and services were made by Allergopharma Joachim Ganzer KG Germany, John Sands Australia, Hasbro, Toll Refrigerated, AstraZeneca Australia, and Nu-Mega Ingredients Pty Ltd. Goods were provided at reduced cost by Auspharm, Allersearch, and Goodman Fielder Foods.Disclosure of potential conflict of interest: C. M. Mellis has consultant arrangements with Merck Sharp & Dohme, Altana Pharma. The rest of the authors have declared that they have no conflict of interest.

PII: S0091-6749(06)00853-0

doi: 10.1016/j.jaci.2006.04.004

The Journal of Allergy and Clinical Immunology
Volume 118, Issue 1 , Pages 53-61 , July 2006

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