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The Journal of Allergy and Clinical Immunology
Volume 117, Issue 6
, Pages 1303-1305
, June 2006
The Faustian bargain of genetic association studies: Bigger might not be better, or at least it might not be good enough
References
- Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. J Clin Invest. 2003;111:1863–1874
- . Arginase: marker, effector, or candidate gene for asthma?. J Clin Invest. 2003;111:1815–1817
- Genetic polymorphisms in arginase I and II and childhood asthma and atopy. J Allergy Clin Immunol. 2006;117:119–126
- . Framework for a fully powered risk engine. Nat Genet. 2005;37:1153
- . Genetic association studies in Thorax. Thorax. 2005;60:357–359
- Association of IL13 with total IgE: Evidence against an inverse association of atopy and diabetes. J Allergy Clin Immunol. 2006;117:1306–1313
- Worldwide variations in prevalence of symptoms of allergic rhinoconjunctivitis in children: the International Study of Asthma and Allergies in Childhood (ISAAC). Pediatr Allergy Immunol. 1997;8:161–176
- . Parental smoking and allergic sensitisation in children. Thorax. 1998;53:117–123
- . Concordance and interrelationship of atopic diseases and markers of allergic sensitization among adult female twins. J Allergy Clin Immunol. 2001;108:901–907
- . Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC II): rationale and methods. Eur Respir J. 2004;24:406–412
- . A meta-analysis of the association between childhood type 1 diabetes and atopic disease. Diabetes Care. 2003;26:2568–2574
- . Hay fever, hygiene, and household size. BMJ. 1989;299:1259–1260
- . Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort. BMJ. 1996;312:1195–1199
- . The natural history of childhood eczema: observations from the British 1958 birth cohort study. Br J Dermatol. 1998;139:834–839
- . Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun. 2006;7:95–100
- An IL-13 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun. 1999;1:61–65
- . IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation. J Clin Invest. 2005;115:747–754
- . Role of regulatory T cells in human diseases. J Allergy Clin Immunol. 2005;116:949–959
- . The role of T regulatory cells in asthma. J Allergy Clin Immunol. 2005;116:996–999
- . Innate immunity: sensing the environment and regulating the regulators. Curr Opin Allergy Clin Immunol. 2003;3:343–346
- . The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev Immunol. 2001;1:69–75
- . Genetics, epigenetics and the environment: switching, buffering, releasing. J Allergy Clin Immunol. 2004;113:381–386
- A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol. 2001;167:5838–5844
- Opposite effects of CD14/-260 on serum IgE levels in children raised in different environments. J Allergy Clin Immunol. 2005;116:601–607
- Evaluation of the CD14/-260 polymorphism and house dust endotoxin exposure in the Barbados Asthma Genetics Study. J Allergy Clin Immunol. 2005;115:1203–1209
- Genome screen for asthma and bronchial hyperresponsiveness: interactions with passive smoke exposure. J Allergy Clin Immunol. 2005;115:1169–1175
- . Rethinking genetic models of asthma: the role of environmental modifiers. Curr Opin Immunol. 2005;17:1–9
- . The sex-specific genetic architecture of quantitative traits in humans. Nat Genet. 2006;38:218–222
- . Learning from discrepancies: CD14 polymorphisms, atopy and the endotoxin switch. Clin Exp Allergy. 2003;33:153–155
- . Gene-environment interactions in asthma and allergies: a new paradigm to understand disease causation. Immunol Allergy Clin North Am. 2005;25:709–721
- Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med. 2002;347:869–877
- Bacterial and fungal components in house dust of farm children, Rudolf Steiner school children and reference children—the PARSIFAL Study. Allergy. 2005;60:611–618
- . Phenotype definition, age, and gender in the genetics of asthma and atopy. Immunol Allergy Clin North Am. 2005;25:621–639
- . The PASTURE project: EU support for the improvement of knowledge about risk factors and preventive factors for atopy in Europe. Allergy. 2006;61:407–413
Disclosure of potential conflict of interest: D. Vercelli receives grant support from the NIH and is on the speakers' bureau for Merck. F. Martinez receives grant support from the NIH and is on the speakers' bureau for Merck.
PII: S0091-6749(06)00736-6
doi: 10.1016/j.jaci.2006.03.030
© 2006 American Academy of Allergy, Asthma and Immunology. Published by Elsevier Inc. All rights reserved.
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The Journal of Allergy and Clinical Immunology
Volume 117, Issue 6
, Pages 1303-1305
, June 2006
