The Journal of Allergy and Clinical Immunology
Volume 118, Issue 1 , Pages 279-280 , July 2006

Oral phenylephrine: An ineffective replacement for pseudoephedrine?

References 

  1. Food and Drug Administration . Establishment of a monograph for OTC cold, cough, allergy, bronchodilator and antiasthmatic drug products. Federal Register. 1976;41:38399–38400Available at: http://www.fda.gov/OHRMS/Dockets/98fr/76-22710.PDF. Accessed December 8, 2005.
  2. Kernan WN, Viscoli CM, Brass LM, Broderick JP, Brott T, Feldmann E, et al. Phenylpropanolamine and the risk of hemorrhagic stroke. N Engl J Med. 2000;343:1826–1832
  3. Hengstmann JH, Goronzy J. Pharmacokinetics of 3H-phenylephrine in man. Eur J Clin Pharmacol. 1982;21:335–341
  4. Kanfer I, Dowse R, Vuma V. Pharmacokinetics of oral decongestants. Pharmacotherapy. 1993;13:116S–128S
  5. Bickerman HA. Physiologic and pharmacologic studies on nasal airway resistance (RN). Presented at a conference sponsored by the Scientific Development Committee of the Proprietary Association. Washington, DC. December 8, 1971. (Available in the Online Repository at www.jacionline.org.)
  6. McLaurin JW, Shipman WF, Rosedale R. Oral decongestants: a double blind comparison study of the effectiveness of four sympathomimetic drugs: objective and subjective. Laryngoscope. 1961;71:54–67
  7. Cohen BM. Clinical and physiologic “significance” in drug-induced changes in nasal flow/resistance. Eur J Clin Pharmacol. 1972;5:81–86
  8. Dressler WE, Myers T, Rankell AS, London SJ, Poetsch CE. A system of rhinomanometry in the clinical evaluation of nasal decongestants. Ann Otol Rhinol Laryngol. 1977;86:310–317
  9. Black MJ, Remsen KA. Rhinitis medicamentosa. CMAJ. 1980;122:881–884
  10. Pullerits T, Praks L, Ristioja V, Lötvall J. Comparison of a nasal glucocorticoid, antileukotriene, and a combination of antileukotriene and antihistamine in the treatment of seasonal allergic rhinitis. J Allergy Clin Immunol. 2002;109:949–955
  11. Hendeles L. Selecting a decongestant. Pharmacotherapy. 1993;13:129S–134S

 Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.

PII: S0091-6749(06)00633-6

doi: 10.1016/j.jaci.2006.03.002

The Journal of Allergy and Clinical Immunology
Volume 118, Issue 1 , Pages 279-280 , July 2006