The Journal of Allergy and Clinical Immunology
Volume 116, Issue 6 , Pages 1213-1219 , December 2005

Irreversible lung function deficits in young adults with a history of childhood asthma

  • Susan L. Limb, MD

      Affiliations

    • From the Division of Allergy and Clinical Immunology
    • ,
  • Kathryn C. Brown, MD

      Affiliations

    • From the Division of Allergy and Clinical Immunology
    • ,
  • Robert A. Wood, MD

      Affiliations

    • Department of Pediatrics
    • ,
  • Robert A. Wise, MD

      Affiliations

    • Divisions of Pulmonology and Critical Care Medicine, Johns Hopkins School of Medicine
    • ,
  • Peyton A. Eggleston, MD

      Affiliations

    • Department of Pediatrics
    • ,
  • James Tonascia, PhD

      Affiliations

    • Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University
    • ,
  • N. Franklin Adkinson Jr., MD

      Affiliations

    • From the Division of Allergy and Clinical Immunology
    • Corresponding Author InformationReprint requests: N. Franklin Adkinson, Jr, MD, JHAAC Rm 2A.62, 5501 Hopkins Bayview Circle, Baltimore, MD 21224.

Received 8 August 2005 ,Revised 13 September 2005 ,Accepted 19 September 2005.

References 

  1. Lange P, Parner J, Vestbo J, Schnohr P, Jensen J. A 15-year follow-up study of ventilatory function in adults with asthma. N Eng J Med. 1998;339:1194–1200
  2. Sears MR, Greene JM, Willan AR, Wiecek EM, Taylor DR, Flannery EM, et al. A longitudinal, population-based, cohort study of childhood asthma followed to adulthood. N Engl J Med. 2003;349:1414–1422
  3. Adkinson NF, Eggleston PA, Eney D, Goldstein EO, Schuberth KC, Bacon JR, et al. A controlled trial of immunotherapy for asthma in allergic children. N Engl J Med. 1997;336:324–331
  4. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med. 1999;159:179–187
  5. American Thoracic Society Lung function testing: selection of reference values and interpretational strategies. A statement of the American Thoracic Society. Am Rev Respir Dis. 1991;144:1202–1218
  6. Sarpong SB, Hamilton RG, Eggleston PA, Adkinson NF. Socioeconomic status and race as risk factors for cockroach allergen exposure and sensitization in children with asthma. J Allergy Clin Immunol. 1996;97:1393–1401
  7. Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. Am J Respir Crit Care Med. 2001;164(suppl):S28–S38
  8. Payne DN, Rogers AV, Adelroth E, Bandi V, Kalpalatha K, Guntupalli KK, et al. Early thickening of the reticular basement membrane in children with difficult asthma. Am J Respir Crit Care Med. 2003;167:78–82
  9. Jenkins HA, Cool C, Szefler SJ, Covar R, Brugman S, Gelfand EW, et al. Histopathology of severe childhood asthma: a case series. Chest. 2003;124:32–41
  10. Rasmussen F, Taylor DR, Flannery EM, Cowan JO, Greene JM, Herbison GP, et al. Risk factors for airway remodeling in asthma manifested by a low postbronchodilator FEV1/vital capacity ratio: a longitudinal population study from childhood to adulthood. Am J Respir Crit Care Med. 2002;165:1480–1488
  11. Grol MH, Gerritsen J, Vonk JM, Schouten JP, Koeter GH, Rijcken B, et al. Risk factors for growth and decline of lung function in asthmatic individuals up to age 42 years. A 30-year follow-up study. Am J Respir Crit Care Med. 1999;160:1830–1837
  12. Jenkins HA, Cherniack R, Szefler SJ, Covar R, Gelfand EW, Spahn JD. A comparison of the clinical characteristics of children and adults with severe asthma. Chest. 2003;124:1318–1324
  13. Bacharier LB, Dawson C, Bloomberg GR, Bender B, Wilson L, Strunk RC, et al. Hospitalization for asthma: atopic, pulmonary function, and psychological correlates among participants in the Childhood Asthma Management Program. Pediatrics. 2003;112:e85–e92
  14. Rona RJ, Gulliford MC, Chinn S. Effects of prematurity and intrauterine growth on respiratory health and lung function in childhood. BMJ. 1993;306:817–820
  15. Raby BA, Celedon JC, Litonjua AA, Phipatanakul W, Sredl D, Oken E, et al. Low-normal gestational age as a predictor of asthma at 6 years of age. Pediatrics. 2004;114:e327–e332
  16. Holt PG, Upham JW, Sly PD. Contemporaneous maturation of immunologic and respiratory functions during early childhood: implications for development of asthma prevention strategies. J Allergy Clin Immunol. 2005;116:16–24
  17. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature. 2002;418:426–430
  18. Busse WW, Rosenwasser LJ. Mechanisms of asthma. J Allergy Clin Immunol. 2003;111(suppl):S799–S804
  19. Weiss ST, Van Natta ML, Zeiger RS. Relationship between increased airway responsiveness and asthma severity in the Childhood Asthma Management Program. Am J Respir Crit Care Med. 2000;162:50–56
  20. Ulrik CS, Backer V. Nonreversible airflow obstruction in life-long nonsmokers with moderate to severe asthma. Eur Respir J. 1999;14:892–896
  21. Covar RA, Spahn JD, Murphy JR, Szefler SJ. Progression of asthma measured by lung function in the Childhood Asthma Management Program. Am J Respir Crit Care Med. 2004;170:234–241
  22. Pauwels RA, Pedersen S, Busse WW, Tan WC, Chen Y, Ohlsson SV, et al. Early intervention with budesonide in mild persistent asthma: a randomized, double-blind trial. Lancet. 2003;361:1071–1076

 Supported by the Philip Morris External Research Program and National Institutes of Health, National Center for Research Resources, grant no. 5M01RR02719 to The Johns Hopkins Bayview General Clinical Research Center.

PII: S0091-6749(05)02110-X

doi: 10.1016/j.jaci.2005.09.024

The Journal of Allergy and Clinical Immunology
Volume 116, Issue 6 , Pages 1213-1219 , December 2005

Article Tools

* Image Usage & Resolution