The Journal of Allergy and Clinical Immunology
Volume 116, Issue 6 , Pages 1235-1241 , December 2005

Genetic pleiotropy between asthma and obesity in a community-based sample of twins

  • Teal S. Hallstrand, MD, MPH

      Affiliations

    • From the Departments of Medicine
    • Corresponding Author InformationReprint requests: Teal S. Hallstrand, MD, MPH, Department of Medicine, Division of Pulmonary and Critical Care, University of Washington, Box 356522, 1959 NE Pacific St, Seattle, WA 98195.
    • ,
  • Mary E. Fischer, PhD

      Affiliations

    • Vietnam Era Twin Registry
    • ,
  • Mark M. Wurfel, MD, PhD

      Affiliations

    • From the Departments of Medicine
    • ,
  • Niloofar Afari, PhD

      Affiliations

    • Psychiatry and Behavioral Sciences, University of Washington
    • University of Washington Twin Registry
    • ,
  • Dedra Buchwald, MD

      Affiliations

    • From the Departments of Medicine
    • University of Washington Twin Registry
    • ,
  • Jack Goldberg, PhD

      Affiliations

    • Epidemiology
    • University of Washington Twin Registry
    • Vietnam Era Twin Registry

Received 2 May 2005 ,Revised 6 September 2005 ,Accepted 7 September 2005.

  • Image Result

    Association between asthma and obesity in the University of Washington Twin Registry. The prevalence of asthma was assessed according to 7 categories of BMI. The association of asthma and obesity was

    Association between asthma and obesity in the University of Washington Twin Registry. The prevalence of asthma was assessed according to 7 categories of BMI. The association of asthma and obesity was assessed in each sex by using mixed-effects ordinal regression. The prevalence of asthma increased with greater BMI in women (P < .001) and marginally in men (P = .07).

  • Image Result
    Path model depicting the additive genetic effects that are common to asthma and obesity plus additive genetic (A), unique environmental (E), and common environmental (C) effects that are unique to eac

    Path model depicting the additive genetic effects that are common to asthma and obesity plus additive genetic (A), unique environmental (E), and common environmental (C) effects that are unique to each phenotype. The parameter estimates are path coefficients, indicating the relative importance of the latent variables A, E, and C to asthma and obesity.

 Supported by National Institutes of Health grants K23HL04231 (TSH), K23HL72923 (MMW), and U19AI38429 (DB).Disclosure of potential conflict of interest: T. Hallstrand has received grants from Merck and Co. Medical School grant awarded to the University of Washington in 2000 and is on the speakers' bureau for Merck and Co. All others—none disclosed.

PII: S0091-6749(05)02064-6

doi: 10.1016/j.jaci.2005.09.016

The Journal of Allergy and Clinical Immunology
Volume 116, Issue 6 , Pages 1235-1241 , December 2005

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