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Volume 117, Issue 1 , Pages 97-102 , January 2006

Parental tobacco smoking is associated with augmented IL-13 secretion in children with allergic asthma

Wojciech Feleszko, MD, PhD
- From the Departments of Pediatric Pneumonology and Allergy
- Dr Feleszko is on a leave of absence at the Department of Pediatric Pneumology and Immunology, Charité Universitäts Medizin, Berlin, Germany.
- Reprint requests: Wojciech Feleszko MD, PhD, Department of Pediatric Pneumology and Allergy, The Medical University Children's Hospital, ul Działdowska 1/3, PL-01-184 Warsaw, Poland.
Anna Zawadzka-Krajewska, MD, PhD
- From the Departments of Pediatric Pneumonology and Allergy
Katarzyna Matysiak, MD
- Unit of Anaesthesiology, The Medical University Children's Hospital, The Medical University of Warsaw
Dorota Lewandowska, MD
- Unit of Anaesthesiology, The Medical University Children's Hospital, The Medical University of Warsaw
Joanna Peradzyńska, MD
- From the Departments of Pediatric Pneumonology and Allergy
Q. Thai Dinh, MD, PhD
- Pneumology and Immunology, Charité School of Medicine, Free University and Humboldt-University, Berlin
Eckard Hamelmann, MD, PhD
- Department of Pediatric Pneumology and Immunology, Charité Universitäts Medizin, Berlin
David A. Groneberg, MD, PhD
- Pneumology and Immunology, Charité School of Medicine, Free University and Humboldt-University, Berlin
Marek Kulus, MD, PhD
- From the Departments of Pediatric Pneumonology and Allergy

Received 18 February 2005 ,Revised 11 August 2005 ,Accepted 7 September 2005.

Levels of IL-5, IL-12, IL-13, and IFN-γ in the fluid phase of NPAs from asthmatic children and healthy control subjects. Boxes indicate the 25th to 75th percentile of the data, the horizontal line acr

Levels of IL-5, IL-12, IL-13, and IFN-γ in the fluid phase of NPAs from asthmatic children and healthy control subjects. Boxes indicate the 25th to 75th percentile of the data, the horizontal line across the box shows the median for the data, and whiskers (lines extending from the boxes) indicate the 5th and 95th percentiles (Mann-Whitney test).
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Concentration of IL-13 in ETS-exposed (passive smokers) and nonexposed (nonsmokers) asthmatic patients and healthy control subjects. Markers indicate each of the samples in the group (undetectable lev

Concentration of IL-13 in ETS-exposed (passive smokers) and nonexposed (nonsmokers) asthmatic patients and healthy control subjects. Markers indicate each of the samples in the group (undetectable levels of IL-13 were plotted at the detection limit, 4.7 pg/mL). Boxes indicate 25th to 75th percentiles of the data, and the horizontal line across the box represents median value. The line across the chart represents the upper limit of the 95% CI of the mean in the control group (Mann-Whitney test).
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Correlation between cytokine levels and serum IgE concentration. IL-13 concentration (A), IL-13/IFN-γ ratio (B), and IL-13/IL-12 ratio (C) in nasopharyngeal secretion and serum IgE concentrations in c

Correlation between cytokine levels and serum IgE concentration. IL-13 concentration (A), IL-13/IFN-γ ratio (B), and IL-13/IL-12 ratio (C) in nasopharyngeal secretion and serum IgE concentrations in children with allergic asthma are shown (log scale). Values represent individual data obtained from 20 subjects studied (as described in the Methods section). The regression line (solid line) indicates the Spearman correlation coefficient (r_s).
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