The Journal of Allergy and Clinical Immunology
Volume 116, Issue 4 , Pages 744-749 , October 2005

IgE antibody quantification and the probability of wheeze in preschool children

  • Angela Simpson, MD, MRCP

      Affiliations

    • From the North West Lung Centre, Wythenshawe Hospital, Manchester
    • Corresponding Author InformationReprint requests: Angela Simpson, MD, North West Lung Centre, Wythenshawe Hospital, Manchester M23 9LT, United Kingdom.
    • ,
  • Lars Soderstrom, MSc

      Affiliations

    • Pharmacia Diagnostics AB, Uppsala
    • ,
  • Staffan Ahlstedt, PhD

      Affiliations

    • Pharmacia Diagnostics AB, Uppsala
    • Institute Environmental Medicine, Centre for Allergy Research, Karolinska Institute, Stockholm
    • ,
  • Clare S. Murray, MD, MRCP

      Affiliations

    • From the North West Lung Centre, Wythenshawe Hospital, Manchester
    • ,
  • Ashley Woodcock, MD, FRCP

      Affiliations

    • From the North West Lung Centre, Wythenshawe Hospital, Manchester
    • ,
  • Adnan Custovic, MD, PhD

      Affiliations

    • From the North West Lung Centre, Wythenshawe Hospital, Manchester

Received 21 January 2005 ,Revised 21 June 2005 ,Accepted 27 June 2005.

  • Image Result

    Fitted predicted probability curves (and 95% CIs) for current wheeze at a given IgE value for mite (A), cat (B), dog (C), and the sum of mite, cat, and dog (D) derived from the logistic regression ana

    Fitted predicted probability curves (and 95% CIs) for current wheeze at a given IgE value for mite (A), cat (B), dog (C), and the sum of mite, cat, and dog (D) derived from the logistic regression analysis.

  • Image Result
    Association between lung function at age 5 years and a sum of mite, cat, and dog allergen-specific IgE antibodies (regression line with 95% CIs).

    Association between lung function at age 5 years and a sum of mite, cat, and dog allergen-specific IgE antibodies (regression line with 95% CIs).

  • Image Result
    Fitted predicted probability curve for persistent wheezing by age 5 years in relation to the sum of mite, cat, and dog allergens derived from the logistic regression analysis.

    Fitted predicted probability curve for persistent wheezing by age 5 years in relation to the sum of mite, cat, and dog allergens derived from the logistic regression analysis.

 Disclosure of potential conflict of interest: L. Soderstrom is employed with Pharmacia Diagnostics AB. S. Ahlstedt is employed with Pharmacia Diagnostics AB. The rest of the authors have none to disclose.Supported by Asthma UK grant number 01/012, Pharmacia Diagnostics and Moulton Charitable Trust.

PII: S0091-6749(05)01532-0

doi: 10.1016/j.jaci.2005.06.032

The Journal of Allergy and Clinical Immunology
Volume 116, Issue 4 , Pages 744-749 , October 2005

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