The Journal of Allergy and Clinical Immunology
Volume 116, Issue 3 , Pages 706-709 , September 2005

The cradle of IgE autoreactivity in atopic eczema lies in early infancy

  • Nadine Mothes, MD

      Affiliations

    • Center for Physiology and Pathophysiology, Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    • ,
  • Bodo Niggemann, MD

      Affiliations

    • Department of Pediatric Pneumology and Immunology, University Hospital Charité, Berlin, Germany
    • ,
  • Claudia Jenneck, MD

      Affiliations

    • Department of Dermatology, University of Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany
    • ,
  • Tobias Hagemann, MD

      Affiliations

    • Department of Dermatology, University of Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany
    • ,
  • Stephan Weidinger, MD

      Affiliations

    • Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
    • ,
  • Thomas Bieber, MD, PhD

      Affiliations

    • Department of Dermatology, University of Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany
    • ,
  • Rudolf Valenta, MD

      Affiliations

    • Center for Physiology and Pathophysiology, Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    • ,
  • Natalija Novak, MD

      Affiliations

    • Department of Dermatology, University of Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany

References 

  1. Illi S, von Mutius E, Lau S, Nickel R, Gruber C, Niggemann B, et al. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol. 2004;113:925–931
  2. Mittermann I, Aichberger KJ, Buender R, Mothes N, Renz H, Valenta R. Autoimmunity and atopic dermatitis. Curr Opin Allergy Clin Immunol. 2004;4:367–371
  3. Valenta R, Maurer D, Steiner R, Seiberler S, Sperr WR, Valent P, et al. Immunoglobullin E responses to human proteins in atopic patients. J Invest Dermatol. 1996;107:203–207
  4. Natter S, Seiberler S, Hufnagl P, Binder BR, Hirschl AM, Ring J, et al. Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients. FASEB J. 1998;12:1559–1569
  5. Valenta R, Duchene M, Pettenburger K, Sillaber C, Valent P, Bettelheim P, et al. Identification of profilin as a novel allergen: IgE autoreactivity in sensitized individuals. Science. 1991;253:557–560
  6. Schmid-Grendelmeier P, Fluckiger S, Disch R, Trautmann A, Wuthrich B, Blaser K, et al. IgE-mediated and T cell-mediated autoimmunity against manganese superoxide dismutase in atopic dermatitis. J Allergy Clin Immunology. 2005;115:1068–1075

 Supported by grants from the Deutsche Forschungsgemeinschaft (DFG NO454/1-2 and DFG FOR 423 NO454/2-3), BONFOR funding of the University of Bonn, and by grant F01815 of the Austrian Science Fund.

PII: S0091-6749(05)01525-3

doi: 10.1016/j.jaci.2005.06.025

The Journal of Allergy and Clinical Immunology
Volume 116, Issue 3 , Pages 706-709 , September 2005

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