The Journal of Allergy and Clinical Immunology
Volume 116, Issue 3 , Pages 706-709 , September 2005

The cradle of IgE autoreactivity in atopic eczema lies in early infancy

  • Nadine Mothes, MD

      Affiliations

    • Center for Physiology and Pathophysiology, Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    • ,
  • Bodo Niggemann, MD

      Affiliations

    • Department of Pediatric Pneumology and Immunology, University Hospital Charité, Berlin, Germany
    • ,
  • Claudia Jenneck, MD

      Affiliations

    • Department of Dermatology, University of Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany
    • ,
  • Tobias Hagemann, MD

      Affiliations

    • Department of Dermatology, University of Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany
    • ,
  • Stephan Weidinger, MD

      Affiliations

    • Department of Dermatology and Allergy, Technical University Munich, Munich, Germany
    • ,
  • Thomas Bieber, MD, PhD

      Affiliations

    • Department of Dermatology, University of Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany
    • ,
  • Rudolf Valenta, MD

      Affiliations

    • Center for Physiology and Pathophysiology, Department of Pathophysiology, Medical University of Vienna, Vienna, Austria
    • ,
  • Natalija Novak, MD

      Affiliations

    • Department of Dermatology, University of Bonn, Sigmund-Freud-Str 25, 53105 Bonn, Germany

  • Image Result

    IgE autoreactivity develops in early infancy. Development of IgE autoreactivity revealed in serum samples obtained from 5 children (1-5) at 2 different time points by immunoblotting with protein extra

    IgE autoreactivity develops in early infancy. Development of IgE autoreactivity revealed in serum samples obtained from 5 children (1-5) at 2 different time points by immunoblotting with protein extracts from the human epithelial cell line A431. The lanes correspond to the age of the children. Molecular weights (kd) are displayed on the left sides of the blots.

 Supported by grants from the Deutsche Forschungsgemeinschaft (DFG NO454/1-2 and DFG FOR 423 NO454/2-3), BONFOR funding of the University of Bonn, and by grant F01815 of the Austrian Science Fund.

PII: S0091-6749(05)01525-3

doi: 10.1016/j.jaci.2005.06.025

The Journal of Allergy and Clinical Immunology
Volume 116, Issue 3 , Pages 706-709 , September 2005

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