The Journal of Allergy and Clinical Immunology
Volume 116, Issue 2 , Pages 279-284 , August 2005

Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus traffic

  • Patrick H. Ryan, MS

      Affiliations

    • From the Department of Environmental Health
    • Corresponding Author InformationReprint requests: Patrick H. Ryan, MS, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056.
  • ,
  • Grace LeMasters, PhD

      Affiliations

    • From the Department of Environmental Health
  • ,
  • Jocelyn Biagini, MS

      Affiliations

    • From the Department of Environmental Health
  • ,
  • David Bernstein, MD

      Affiliations

    • Department of Internal Medicine, Division of Immunology, University of Cincinnati
  • ,
  • Sergey A. Grinshpun, PhD

      Affiliations

    • From the Department of Environmental Health
  • ,
  • Rakesh Shukla, PhD

      Affiliations

    • From the Department of Environmental Health
  • ,
  • Kimberly Wilson, MS

      Affiliations

    • From the Department of Environmental Health
  • ,
  • Manuel Villareal, MD

      Affiliations

    • Department of Internal Medicine, Division of Immunology, University of Cincinnati
  • ,
  • Jeff Burkle, BS

      Affiliations

    • From the Department of Environmental Health
  • ,
  • James Lockey, MD

      Affiliations

    • From the Department of Environmental Health

Received 15 March 2005 ,Revised 9 May 2005 ,Accepted 10 May 2005.

References 

  1. Peden DB. The epidemiology and genetics of asthma risk associated with air pollution. J Allergy Clin Immunol. 2005;115:213–219
  2. Riedl M, Diaz-Sanchez D. Biology of diesel exhaust effects on respiratory function. J Allergy Clin Immunol. 2005;115:221–228
  3. Peden DB. Development of atopy and asthma: candidate environmental influences and important periods of exposure. Environ Health Perspect. 2000;108:475–482
  4. Pandya RJ, Solomon G, Kinner A, Balmes JR. Diesel exhaust and asthma: hypotheses and molecular mechanisms of action. Environ Health Perspect. 2002;110:103–112
  5. Diaz-Sanchez D, Tsien A, Casillas A, Dotson AR, Saxon A. Enhanced nasal cytokine production in human beings after in vivo challenge with diesel exhaust particles. J Allergy Clin Immunol. 1996;98:114–123
  6. US Environmental Protection Agency (EPA). Health assessment document for diesel engine exhaust. Prepared by the National Center for Environmental Assessment, Washington, DC, for the Office of Transportation and Air Quality; EPA/600/8–90/057F. 2002. Available at: http://www.epa.gov/ncea.
  7. Knox RB, Suphioglu C, Taylor P, Desai R, Watson HC, Peng JL, et al. Major grass pollen allergen Lol p 1 binds to diesel exhaust particles: implications for asthma and air pollution. Clin Exp Allergy. 1997;27:246–251
  8. Ormstad H. Suspended particulate matter in indoor air: adjuvants and allergen carriers. Toxicology. 2000;152:53–68
  9. Diaz-Sanchez D, Tsien A, Fleming J, Saxon A. Combined diesel exhaust particulate and ragweed allergen challenge enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2 type pattern. J Immunol. 1997;158:2406–2413
  10. Fujieda S, Diaz-Sanchez D, Saxon A. Combined nasal challenge with diesel exhaust particles and allergen induces in vivo IgE isotype switching. Am J Respir Cell Mol Biol. 1998;19:507–512
  11. Fujimaki H, Nohara O, Ichinose T, Watanabe N, Saito S. IL-4 production in mediastinal lymph node cells in mice intratracheally instilled with diesel exhaust particulates and antigen. Toxicology. 1994;92:261–268
  12. LeMasters GK, Wilson KA, Levin L, Bernstein DI, Lockey JE, Villareal M, et al. Validation of a population-based brief allergy symptoms questionnaire. Abstract presented at: American Thoracic Society International Conference; May 16-21, 2003; Seattle (WA).
  13. Jenkins MA, Clarke JR, Carlin JB, Robertson CF, Hopper JL, Dalton MF, et al. Validation of questionnaire and bronchial hyperresponsiveness against respiratory physician assessment in the diagnosis of asthma. Int J Epidemiol. 1996;25:609–616
  14. Brunekreef B, Janssen NAH, de Hartog J, Harssema H, Knape M, van Vliet P. Air pollution from truck traffic and lung function in children living near motorways. Epidemiology. 1997;8:298–303
  15. van Vliet P, Knape M, de Hartog J, Janssen N, Harssema H, Brunekreef B. Motor vehicle exhaust and chronic respiratory symptoms in children living near freeways. Environ Res. 1997;74:122–132
  16. Venn AJ, Lewis SA, Cooper M, Hubbard R, Britton J. Living near a main road and the risk of wheezing illness in children. Am J Respir Crit Care Med. 2001;164:2177–2180
  17. Wilkinson P, Elliott P, Grundy C, Shaddick G, Thakrar B, Walls P, et al. Case-control study of hospital admission with asthma in children aged 5-14 years: relation with road traffic in north west London. Thorax. 1999;54:1070–1074
  18. Lin S, Munsie JP, Hwang S, Fitzgerald E, Cayo MR. Childhood asthma: hospitalization and residential exposure to state route traffic. Environ Res. 2002;88:73–81
  19. Janssen NAH, Brunekreef B, van Vliet P, Aarts F, Meliefste K, Harssema H, et al. The relationship between air pollution from heavy traffic and allergic sensitization, bronchial hyperresponsiveness, and respiratory symptoms in Dutch schoolchildren. Environ Health Perspect. 2003;111:1512–1518
  20. Reponen T, Grinshpun SA, Trakumas S, Martuzevicius D, Wang Z, LeMasters G, et al. Concentration gradient patterns of aerosol particles near interstate highways in the Greater Cincinnati airshed. J Environ Monit. 2003;5:557–562
  21. Solomon G, Campbell T, Feuer G, Masters J, Samkian A, Paul K. No breathing in the aisles: Diesel exhaust inside school buses. Natural Resources Defense Council, Coalition for Clean Air. 2001. Available at: http://www.nrdc.org/air/transportation/schoolbus/sbusinx.asp.
  22. Shah S, Cocker D, Miller JW, Norbeck JM. Emission rates of particulate matter and elemental and organic carbon from in-use diesel engines. Environ Sci Technol. 2004;38:2544–2550
  23. Tong HY, Hung WT, Cheung CS. On-road vehicle emissions and fuel consumption in urban driving conditions. J Air Waste Manag Assoc. 2000;50:543–554
  24. Unal A, Frey HC, Rouphail NM. Quantification of highway vehicle emissions hot spots based upon on-board measurements. J Air Waste Manag Assoc. 2004;54:130–140
  25. Hirsch T, Weiland SK, von Mutius E, Safeca AF, Grafe H, Csaplovics E, et al. Inner city air pollution and respiratory health and atopy in children. Eur Respir J. 1999;14:669–677
  26. Ciccone G, Forastiere F, Agabiti N, Biggeri A, Bisanti L, Chellini E, et al. Road traffic and adverse respiratory effects in children. SIDRIA Collaborative Group. Occup Environ Med. 1998;55:771–778
  27. Shima M, Nitta Y, Adachi M. Traffic related air pollution and respiratory symptoms in children living along trunk roads in Chiba Prefecture, Japan. J Epidemiol. 2003;13:108–119
  28. Brauer M, Hoek G, Van Vliet P, Meliefste K, Fischer PH, Wijga A, et al. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. Am J Respir Crit Care Med. 2002;166:1092–1098
  29. Norris G, YoungPong S, Koenig J, Larson T, Sheppard L, Stout J. An association between fine particles and asthma emergency department visits for children in Seattle. Environ Health Perspect. 1999;110:489–493
  30. Pino P, Walter T, Oyarzun M, Villegas R, Romieu I. Fine particulate matter and wheezing illnesses in the first year of life. Epidemiology. 2004;15:702–708
  31. Shima M, Nitta Y, Ando M, Adachi M. Effects of air pollution on the prevalence and incidence of asthma in children. Arch Environ Health. 2002;57:529–535
  32. van der Zee S, Hoek G, Boezen HM, Shouten J, van Wijnen JH, Brunekreef B. Acute effects of urban air pollution on respiratory health of children with and without chronic respiratory symptoms. Occup Environ Med. 1999;56:802–813
  33. Jalaludin BB, O'Toole BI, Leeder SR. Acute effects of urban ambient air pollution on respiratory symptoms, asthma medication use, and doctor visits for asthma in a cohort of Australian children. Environ Res. 2004;95:32–42
  34. Penttinen P, Timonen KL, Tiittanen P, Mirme A, Ruuskanen J, Pekkanen J. Ultrafine particles in urban air and respiratory health among adult asthmatics. Eur Respir J. 2001;17:428–435
  35. Schwartz J, Neas LM. Fine particles are more strongly associated than coarse particles with acute respiratory health effects in schoolchildren. Epidemiology. 2000;11:6–10
  36. Brauer M, Avila-Casado C, Fortoul TI, Vedal S, Stevens B, Churg A. Air pollution and retained particles in the lung. Environ Health Perspect. 2001;109:1039–1043
  37. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, et al. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect. 2003;111:455–460
  38. Sheriff A, Peters TJ, Henderson J, Strachan D, ALSPAC Study Team . Risk factor associations with wheezing patterns in children followed longitudinally from birth to 3(1/2) years. Int J Epidemiol. 2001;30:1473–1484
  39. El-Sharif N, Abdeen Z, Barghuthy F, Nemery B. Familial and environmental determinants for wheezing and asthma in a case-control study of school children in Palestine. Clin Exp Allergy. 2003;33:176–186
  40. Arshad SH, Kurukulaaratchy RJ, Fenn M, Matthews S. Early life risk factors for current wheeze, asthma, and bronchial hyperresponsiveness at 10 years of age. Chest. 2005;127:502–508
  41. London SJ, Gauderman J, Avol E, Rappaport EB, Peters JM. Family history and the risk of early-onset persistent, early onset transient, and late-onset asthma. Epidemiology. 2001;12:577–583
  42. Grant EN, Lyttle CS, Weiss KB. The relation of socioeconomic factors and racial/ethnic differences in the US asthma mortality. Am J Public Health. 2000;90:1923–1925
  43. Joseph CLM, Ownby DR, Peterson EL, Johnson CC. Racial differences in physiologic parameters related to asthma among middle-class children. Chest. 2000;117:1336–1344
  44. Simon PA, Zeng Z, Wold CM, Haddock W, Fielding JE. Rate of childhood asthma and associated morbidity in Los Angeles County: impacts of race/ethnicity and income. J Asthma. 2003;40:535–543
  45. Taussig L, Wright A, Holberg C, Halonen M, Morgan W, Martinez F. Tucson Children's Respiratory Study: 1980 to present. J Allergy Clin Immunol. 2003;111:661–675

 Supported by grants ES11170 and ES10957 from the National Institute of Environmental Health Sciences.Disclosure of potential conflict of interest: S. A. Grinshpun has received grants–research support from the National Institute of Environmental Health Sciences. M. Villareal has consultant arrangements with Aventis, has stock or other equity ownership with Pfizer, and is on the speakers' bureaus for AstraZeneca, UCB Pharma, Pfizer, Aventis, and GlaxoSmithKline. There are not other potential conflicts to disclose.

PII: S0091-6749(05)01309-6

doi: 10.1016/j.jaci.2005.05.014

The Journal of Allergy and Clinical Immunology
Volume 116, Issue 2 , Pages 279-284 , August 2005