The Journal of Allergy and Clinical Immunology
Volume 116, Issue 2 , Pages 279-284, August 2005

Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus traffic

  • Patrick H. Ryan, MS

      Affiliations

    • From the Department of Environmental Health
    • Corresponding Author InformationReprint requests: Patrick H. Ryan, MS, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056.
  • ,
  • Grace LeMasters, PhD

      Affiliations

    • From the Department of Environmental Health
  • ,
  • Jocelyn Biagini, MS

      Affiliations

    • From the Department of Environmental Health
  • ,
  • David Bernstein, MD

      Affiliations

    • Department of Internal Medicine, Division of Immunology, University of Cincinnati
  • ,
  • Sergey A. Grinshpun, PhD

      Affiliations

    • From the Department of Environmental Health
  • ,
  • Rakesh Shukla, PhD

      Affiliations

    • From the Department of Environmental Health
  • ,
  • Kimberly Wilson, MS

      Affiliations

    • From the Department of Environmental Health
  • ,
  • Manuel Villareal, MD

      Affiliations

    • Department of Internal Medicine, Division of Immunology, University of Cincinnati
  • ,
  • Jeff Burkle, BS

      Affiliations

    • From the Department of Environmental Health
  • ,
  • James Lockey, MD

      Affiliations

    • From the Department of Environmental Health

Received 15 March 2005; received in revised form 9 May 2005; accepted 10 May 2005. published online 16 June 2005.

Cincinnati, Ohio

Background

Previous studies of air pollution have not examined the association between exposure to varying types, distance, and amounts of traffic and wheezing in very young infants.

Objective

We sought to determine the relationship between types of traffic, traffic volume, and distance and wheezing among infants less than 1 year of age.

Methods

A geographic information system and a classification scheme were developed to categorize infants enrolled in the study as living near moving truck and bus traffic (highway >50 miles per hour, >1000 trucks daily, <400 m), stop-and-go truck and bus traffic (<50 miles per hour, <100 m), or unexposed and not residing near either. Symptom data were based on health questionnaires administered to parents when the infants were 6 months of age and monthly health diaries.

Results

Infants living very near (<100 m) stop-and-go bus and truck traffic had a significantly increased prevalence of wheezing (adjusted odds ratio, 2.50; 95% CI, 1.15-5.42) when compared with unexposed infants. The prevalence of wheezing among nonwhite infants was at least twice that of white infants, regardless of exposure. Infants living less than 400 m from a high volume of moving traffic, however, did not have an increased prevalence of wheezing.

Conclusion

These results suggest that the distance from and type of traffic exposures are more significant risk factors than traffic volume for wheezing in early infancy.

Key words: Diesel, traffic, truck, bus, wheezing, Geographic Information System, infants

Abbreviations used: CCAAPS, Cincinnati Childhood Allergy and Air Pollution Study, DEP, Diesel exhaust particle, GIS, Geographic information system, mph, Miles per hour, OR, Odds ratio, PM, Particulate matter, SPT, Skin prick test

 

 Supported by grants ES11170 and ES10957 from the National Institute of Environmental Health Sciences.Disclosure of potential conflict of interest: S. A. Grinshpun has received grants–research support from the National Institute of Environmental Health Sciences. M. Villareal has consultant arrangements with Aventis, has stock or other equity ownership with Pfizer, and is on the speakers' bureaus for AstraZeneca, UCB Pharma, Pfizer, Aventis, and GlaxoSmithKline. There are not other potential conflicts to disclose.

PII: S0091-6749(05)01309-6

doi:10.1016/j.jaci.2005.05.014

The Journal of Allergy and Clinical Immunology
Volume 116, Issue 2 , Pages 279-284, August 2005