The Journal of Allergy and Clinical Immunology
Volume 116, Issue 1 , Pages 60-64 , July 2005

Genetic regulation of IgE responses: Achilles and the tortoise

  • Donata Vercelli

      Affiliations

    • Corresponding Author InformationReprint requests: Donata Vercelli, MD, Arizona Respiratory Center, University of Arizona Health Sciences Center, 1501 N Campbell Avenue, Rm 2349, Tucson, AZ 85724.

Received 17 April 2005 ,Accepted 19 April 2005.

References 

  1. Geha R, Jabara H, Brodeur S. The regulation of immunoglobulin E class-switch recombination. Nat Rev Immunol. 2003;3:721–732
  2. Vercelli D. Innate immunity: sensing the environment and regulating the regulators. Curr Opin Allergy Clin Immunol. 2003;3:343–346
  3. Vercelli D. Genetics, epigenetics and the environment: switching, buffering, releasing. J Allergy Clin Immunol. 2004;113:381–386
  4. Hoffjan S, Nicolae D, Ober C. Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir Res. 2003;4:14
  5. Graves PE, Kabesch M, Halonen M, et al. A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol. 2000;105:506–513
  6. Vladich FD, Brazille SM, Stern D, Peck ML, Ghittoni R, Vercelli D. IL-13 R130Q, a common variant associated with allergy and asthma, enhances effector mechanisms essential for human allergic inflammation. J Clin Invest. 2005;115:747–754
  7. Eder W, Klimecki WT, Yu L, von Mutius E, Riedler J, Braun-Fahrlander C, et al. Toll-like receptor 2 as a major gene for asthma in children of European farmers. J Allergy Clin Immunol. 2004;113:482–488
  8. Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FD. A polymorphism in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum IgE. Am J Respir Cell Mol Biol. 1999;20:976–983
  9. Hobbs K, Negri J, Klinnert M, Rosenwasser LJ, Borish L. Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma. Am J Respir Crit Care Med. 1998;158:1958–1962
  10. Silverman ES, Palmer LJ, Subramaniam V, Hallock A, Mathew S, Vallone J, et al. Transforming growth factor-β1 promoter polymorphism C-509T is associated with asthma. Am J Respir Crit Care Med. 2004;169:214–219
  11. Traidl-Hoffmann C, Mariani V, Hochrein H, Karg K, Wagner H, Ring J, et al. Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization. J Exp Med. 2005;201:627–636
  12. Oguma T, Palmer LJ, Birben E, Sonna LA, Asano K, Lilly CM. Role of prostanoid DP receptor variants in susceptibility to asthma. N Engl J Med. 2004;351:1752–1763
  13. Murphy KM, Reiner SL. The lineage decisions of helper T cells. Nat Rev Immunol. 2002;2:933–944
  14. Hwang ES, Szabo SJ, Schwartzberg PL, Glimcher LH. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005;307:430–433
  15. Pykalainen M, Kinos R, Valkonen S, Rydman P, Kilpelainen M, Laitinen LA, et al. Association analysis of common variants of STAT6, GATA3, and STAT4 to asthma and high serum IgE phenotypes. J Allergy Clin Immunol. 2005;115:80–87
  16. Tantisira KG, Hwang ES, Raby BA, Silverman ES, Lake SL, Richter BG, et al. TBX21: a functional variant predicts improvement in asthma with the use of inhaled corticosteroids. Proc Natl Acad Sci U S A. 2004;101:18099–18104
  17. Schedel M, Carr D, Klopp N, Woitsch B, Illig T, Stachel D, et al. A signal transducer and activator of transcription 6 haplotype influences the regulation of serum IgE levels. J Allergy Clin Immunol. 2004;114:1100–1105
  18. Basehore MJ, Howard TD, Lange LA, Moore WC, Hawkins GA, Marshik PL, et al. A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects. J Allergy Clin Immunol. 2004;114:80–87
  19. Chen W, Ericksen MB, Levin LS, Khurana Hershey GK. Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants. J Allergy Clin Immunol. 2004;114:553–560
  20. Howard TD, Whittaker PA, Zaiman AL, Koppelman GH, Xu J, Hanley MT, et al. Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. Am J Respir Cell Mol Biol. 2001;25:377–384
  21. Heinzmann A, Mao X, Akaiwa M, Kreomer RT, Gao P, Ohshima K, et al. Genetic variants of IL-13 signalling and human asthma and atopy. Hum Mol Genet. 2000;9:549–559
  22. Mostecki J, Klimecki WJ, Graves PE, Miller RL, Vanpeer M, Martinez FD, et al. Single nucleotide polymorphism in the SOCS-1 promoter is associated with lower IgE levels in asthma patients. 12th International Congress of Immunology, Montreal, Canada 2004;M36.131.
  23. Stern D, Eder W, Tebow G, Lohman IC, Braun-Fahrländer C, Riedler J, et al. Rethinking Th2 antibody responses and allergic sensitization. Novartis Foundation. 2004;257:25–37
  24. Shirakawa T, Li A, Dubowitz M, Dekker JW, Shaw AE, Faux JA, et al. Association between atopy and variants of the β subunit of the high-affinity immunoglobulin E receptor. Nat Genet. 1994;7:125–129
  25. Hinds DA, Stuve LL, Nilsen GB, Halperin E, Eskin E, Ballinger DG, et al. Whole-genome patterns of common DNA variation in three human populations. Science. 2005;307:1072–1079

 Disclosure of potential conflict of interest: D. Vercelli—none disclosed.

PII: S0091-6749(05)01269-8

doi: 10.1016/j.jaci.2005.04.031

The Journal of Allergy and Clinical Immunology
Volume 116, Issue 1 , Pages 60-64 , July 2005

Article Tools

* Image Usage & Resolution