The Journal of Allergy and Clinical Immunology
Volume 116, Issue 2 , Pages 299-304 , August 2005

Duration of postviral airway hyperresponsiveness in children with asthma: Effect of atopy

Received 11 November 2004 ,Revised 28 March 2005 ,Accepted 4 April 2005.

References 

  1. Lowe L, Custovic MS, Woodcock A. Childhood asthma. Curr Allergy Asthma Rep. 2004;4:159–165
  2. Weiss ST, Van Natta ML, Zeiger RS. Relationship between increased airway responsiveness and asthma severity in the childhood asthma management program. Am J Respir Crit Care Med. 2000;162:50–56
  3. Louis-Philippe B. Physiopathology of airway hyperresponsiveness. Curr Allergy Asthma Rep. 2003;3:166–171
  4. Empey DW, Laitinen LA, Jacobs L, Gold WM, Nadel JA. Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection. Am Rev Respir Dis. 1976;113:131–139
  5. Gern JE, Calhoun W, Swenson C, Shen G, Busse WW. Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects. Am Respir Crit Care Med. 1997;155:1872–1876
  6. Grunberg K, Kuijpers EA, de Klerk EP, de Gouw HW, Kroes AC, Dick EC, et al. Effects of experimental rhinovirus 16 infection on airway hyperresponsiveness to bradykinin in asthmatic subjects in vivo. Am J Respir Crit Care Med. 1997;155:833–838
  7. Cheung D, Dick EC, Timmers MC, de Klerk EP, Spaan WJ, Sterk PJ. Rhinovirus inhalation causes long-lasting excessive airway narrowing in response to methacholine in asthmatic subjects in vivo. Am J Respir Crit Care Med. 1995;152:1490–1496
  8. Jafri HS, Chavez-Bueno S, Mejias A, Gomez AM, Rios AM, Nassi SS, et al. Respiratory syncytial virus induces pneumonia, cytokine response, airway obstruction, and chronic inflammatory infiltrates associated with long-term airway hyperresponsiveness in mice. J Infect Dis. 2004;189:1856–1865
  9. Folkerts G, Busse WW, Nijkamp FP, Sorkness R, Gern JE. Virus induced airway hyperresponsiveness and asthma. Am J Respir Crit Care Med. 1998;157:1708–1720
  10. Walter MJ, Morton JD, Kajiwara N, Agapov E, Holtzman MJ. Viral induction of a chronic asthma phenotype and genetic segregation from the acute response. J Clin Invest. 2002;110:165–175
  11. Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995;310:1225–1229
  12. Papadopoulos NG, Psarras S, Manoussakis E, Saxoni-Papageorgiou P. The role of respiratory viruses in the origin and exacerbations of asthma. Curr Opin Allergy Clin Immunol. 2003;3:39–44
  13. Bardin PG, Sanderson G, Robinson BS, Holgate ST, Tyrrell DA. Experimental rhinovirus infection in volunteers. Eur Respir J. 1996;9:2250–2255
  14. Christodoulopoulos P, Cameron L, Nakamura Y, Lemiere C, Muro S, Dugas M, et al. TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression. J Allergy Clin Immunol. 2001;107:586–591
  15. Martinez FD. Links between pediatric and adult asthma. J Allergy Clin Immunol. 2001;107(suppl):S449–S455
  16. Warner JO. Bronchial hyperresponsiveness, atopy, airway inflammation and asthma. Pediatr Allergy Immunol. 1998;9:55–56
  17. Postma DS, Koppelman GH, Meyers DA. The genetics of atopy and airway hyperresponsiveness. Am J Respir Crit Care Med. 2000;162(suppl):S118–S123
  18. Davies DE, Wicks J, Powell RM, Puddicombe SM, Holgate ST. Airway remodeling in asthma: new insights. J Allergy Clin Immunol. 2003;111:215–226
  19. Nelson HS, Szefler SJ, Jacobs J, Huss K, Shapiro G, Sternberg AL. The relationships among environmental allergen sensitization, allergen exposure, pulmonary function, and bronchial hyperresponsiveness in the Childhood Asthma Management Program. J Allergy Clin Immunol. 1999;104:775–785
  20. Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL. A defective type 1 response to rhinovirus in atopic asthma. Thorax. 2002;57:328–332
  21. Brooks GD, Buchta KA, Swenson CA, Gern JE, Busse WW. Rhinovirus-induced interferon-γ and airway responsiveness in asthma. Am J Respir Crit Care Med. 2003;168:1091–1094
  22. Papadopoulos NG, Stanciu LA, Papi A, Holgate ST, Johnston SL. Rhinovirus-induced alterations on peripheral blood mononuclear cell phenotype and costimulatory molecule expression in normal and atopic asthmatic subjects. Clin Exp Allergy. 2002;32:537–542
  23. Global Strategy for Asthma Management and Prevention. Bethesda (MD): National Institutes of Health, National Heart, Lung and Blood Institute; 2002;Publication no. 02-3659
  24. Cain H. Bronchoprovocation testing. Clin Chest Med. 2001;22:651–659
  25. American Thoracic Society . Guidelines for methacholine and exercise challenge testing-1999. Am J Respir Crit Care Med. 2000;161:309–329
  26. Cockcroft DW. How best to measure airway responsiveness. Am J Respir Crit Care Med. 2001;163:1514–1515
  27. American Thoracic Society. Standarization of spirometry: 1994 update. Am J Respir Crit Care Med. 1995;152:1107–1136
  28. Papadopoulos NG, Sanderson G, Hunter J, Johnston SL. Rhinovirus replicate effectively at lower airway temperatures. J Med Virol. 1999;58:100–104
  29. Papadopoulos NG, Hunter J, Sanderson G, Meyer J, Johnston SL. Rhinovirus identification by BglI digestion of picornavirus RT-PCR amplicons. J Virol Methods. 1999;80:179–185
  30. Papadopoulos NG, Moustaki M, Tsolia M, Bossios A, Astra E, Prezerakou A, et al. Association of rhinovirus infection with increased disease severity in acute bronchiolitis. Am Respir Crit Care Med. 2002;165:1285–1289
  31. Sub-Committee on Skin Tests of the European Academy of Allergology and Clinical Immunology. Skin tests used in type I allergy testing [position paper]. Allergy 1989;44 Suppl 10:1-59.
  32. Skoner DP, Doyle WJ, Seroky J, Fireman P. Lower airway responses to influenza A virus in healthy allergic and nonallergic subjects. Am J Respir Crit Care Med. 1996;154:661–664
  33. Fleming HE, Little FF, Schnurr D, Avila PC, Wong H, Liu J, et al. Rhinovirus-16 colds in healthy and in asthmatic subjects: similar changes in upper and lower airways. Am J Respir Crit Care Med. 1999;160:100–108
  34. Grunberg K, Timmers MC, Smits HH, de Klerk EP, Dick EC, Spaan WJ, et al. Effect of experimental rhinovirus 16 colds on airway hyperresponsiveness to histamine and interleukin-8 in nasal lavage in asthmatic subjects in vivo. Clin Exp Allergy. 1997;27:36–45
  35. Schwarze J, Gelfand EW. Respiratory viral infections as promoters of allergic sensitization and asthma in animal models. Eur Respir J. 2002;19:341–349
  36. Folkerts G, Nijkamp FP. Virus-induced airway hyperresponsiveness. Role of inflammatory cells and mediators. Am J Respir Crit Care Med. 1995;151:1666–1674
  37. Matsuse H, Behera AK, Kumar M, Rabb H, Lockey RF, Mohapatra SS. Recurrent respiratory syncytial virus infections in allergen-sensitized mice lead to persistent airway inflammation and hyperresponsiveness. J Immunol. 2000;164:6583–6592
  38. Trigg CJ, Nicholson KG, Wang JH, Ireland DC, Jordan S, Duddle JM, et al. Bronchial inflammation and the common cold: a comparison of atopic and non-atopic individuals. Clin Exp Allergy. 1996;26:665–676
  39. Sears MR, Burrows B, Herbison GP, Holdaway MD, Flannery EM. Atopy in childhood. II. Relationship to airway responsiveness, hay fever and asthma. Clin Exp Allergy. 1993;23:949–956
  40. Lemanske RF, Dick EC, Swenson CA, Vrtis RF, Buse WW. Rhinovirus upper respiratory tract infection increases airway hyperreactivity and late asthmatic reactions. J Clin Invest. 1989;83:1–10
  41. Calhoun WJ, Dick EC, Schwartz LB, Busse WW. A common cold virus, rhinovirus 16, potentiates airway inflammation after segmental antigen bronchoprovocation in allergic subjects. J Clin Invest. 1994;94:2200–2208
  42. Green RM, Custovic A, Sanderson G, Hunter J, Johnston SL, Woodcock A. Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study. BMJ. 2002;324:763–768
  43. Papadopoulos NG, Psarros F, Manoussakis E, Hatzipsalti M, Bossios A, Syrigou E, et al. Association of respiratory viral infections with disease exacerbations in patients with allergen-driven seasonal asthma and hay fever. [abstract] Allergy. 2002;57:295
  44. Avila PC. Interactions between allergic inflammation and respiratory viral infections. J Allergy Clin Immunol. 2000;106:829–831
  45. de Kluijver J, Evertse CE, Sont JK, Schrumpf JA, van Zeijl-van der Ham CJ, Dick CR, et al. Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure?. Am J Respir Crit Care Med. 2003;168:1174–1180
  46. Parry DE, Busse WW, Sukow KA, Dick CR, Swenson C, Gern JE. Rhinovirus-induced PBMC responses and outcome of experimental infection in allergic subjects. J Allergy Clin Immunol. 2000;105:692–698
  47. Busse WW, Gern JE. Do allergies protect against the effects of a rhinovirus cold?. J Allergy Clin Immunol. 2000;105:889–891
  48. Corne JM, Marshall C, Smith S, Schreiber J, Sanderson G, Holgate ST, et al. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet. 2002;359:831–834
  49. Prescott SL. Allergy: when does it begin and where will it end?. Allergy. 2003;58:864–867
  50. Smart JM, Kemp AS. Ontogeny of T-helper 1 and T-helper 2 cytokine production in childhood. Pediatr Allergy Immunol. 2001;12:181–187
  51. Wark PA, Johnston SL, Bucchieri F, Powell R, Puddicombe S, Laza-Stanca V, et al. Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med. 2005;201:937–947
  52. Boulet LP. Asymptomatic airway hyperresponsiveness: a curiosity or an opportunity to prevent asthma?. Am J Respir Crit Care Med. 2003;167:371–378
  53. Arruda LK, Sole D, Baena-Cagnani CE, Naspitz CK. Risk factors for asthma and atopy. Curr Opin Allergy Clin Immunol. 2005;5:153–159
  54. Van den Toorn LM, Overbeek SE, de Jongste JC, Leman K, Hoogsteden HC, Prins JB. Airway inflammation is present during clinical remission of atopic asthma. Am J Respir Crit Care Med. 2001;164:2107–2113

 Disclosure of potential conflict of interest: N. Papadopoulos has received grants–research support from GlaxoSmithKline and AstraZeneca. P. Saxoni-Papageorgiou has received grants–research support from Novartis and Schering-Plough. All other authors—none disclosed.

PII: S0091-6749(05)00713-X

doi: 10.1016/j.jaci.2005.04.007

The Journal of Allergy and Clinical Immunology
Volume 116, Issue 2 , Pages 299-304 , August 2005

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