The Journal of Allergy and Clinical Immunology
Volume 116, Issue 2 , Pages 299-304 , August 2005

Duration of postviral airway hyperresponsiveness in children with asthma: Effect of atopy

Received 11 November 2004 ,Revised 28 March 2005 ,Accepted 4 April 2005.

  • Image Result

    Linear regression model of AHR changes from the 10th day to the seventh week after a single URI in atopic (A) and nonatopic (B) children with intermittent virus-induced asthma. A significant and time-

    Linear regression model of AHR changes from the 10th day to the seventh week after a single URI in atopic (A) and nonatopic (B) children with intermittent virus-induced asthma. A significant and time-dependent AHR decrease is observed in both cases. The predicted time for AHR to return to baseline did not differ between the groups.

  • Image Result
    Kaplan-Meyer diagram of PC20 return to its respective baseline value after one or more naturally occurring URIs during a 9-month period in atopic and nonatopic asthmatic children. The difference is si

    Kaplan-Meyer diagram of PC20 return to its respective baseline value after one or more naturally occurring URIs during a 9-month period in atopic and nonatopic asthmatic children. The difference is significant (P=.0068, survival analysis).

  • Image Result
    Upper respiratory tract symptom exacerbations, colds, and asthma exacerbations experienced during a 9-month period in atopic (open bars) and nonatopic (filled bars) children with intermittent asthma.

    Upper respiratory tract symptom exacerbations, colds, and asthma exacerbations experienced during a 9-month period in atopic (open bars) and nonatopic (filled bars) children with intermittent asthma. ∗P < .05, #P=.06.

 Disclosure of potential conflict of interest: N. Papadopoulos has received grants–research support from GlaxoSmithKline and AstraZeneca. P. Saxoni-Papageorgiou has received grants–research support from Novartis and Schering-Plough. All other authors—none disclosed.

PII: S0091-6749(05)00713-X

doi: 10.1016/j.jaci.2005.04.007

The Journal of Allergy and Clinical Immunology
Volume 116, Issue 2 , Pages 299-304 , August 2005

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