The Journal of Allergy and Clinical Immunology
Volume 116, Issue 1 , Pages 49-55 , July 2005

The Canadian Childhood Asthma Primary Prevention Study: Outcomes at 7 years of age

  • Moira Chan-Yeung, MB

      Affiliations

    • From the Occupational and Environmental Lung Disease Unit, Department of Medicine
    • Corresponding Author InformationReprint requests: Moira Chan-Yeung, MB, Respiratory Division, Department of Medicine, 2775, Heather Street, Vancouver, BC, Canada V5Z 3J5.
    • ,
  • Alexander Ferguson, MD

      Affiliations

    • Division of Allergy, Department of Pediatrics, University of British Columbia, Vancouver
    • ,
  • Wade Watson, MD

      Affiliations

    • Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, Manitoba Institute of Child Health, University of Manitoba, Winnipeg
    • ,
  • Helen Dimich-Ward, PhD

      Affiliations

    • From the Occupational and Environmental Lung Disease Unit, Department of Medicine
    • ,
  • Roxanne Rousseau, BSc

      Affiliations

    • From the Occupational and Environmental Lung Disease Unit, Department of Medicine
    • ,
  • Marilyn Lilley, RN

      Affiliations

    • Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, Manitoba Institute of Child Health, University of Manitoba, Winnipeg
    • ,
  • Anne DyBuncio, BSc

      Affiliations

    • From the Occupational and Environmental Lung Disease Unit, Department of Medicine
    • ,
  • Allan Becker, MD

      Affiliations

    • Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, Manitoba Institute of Child Health, University of Manitoba, Winnipeg

Received 18 January 2005 ,Revised 23 March 2005 ,Accepted 24 March 2005.

References 

  1. Arshad SH, Matthews S, Gant C, Hide DW. Effect of allergen avoidance on development of allergic disorders in infancy. Lancet. 1992;339:1493–1497
  2. Custovic A, Simpson BM, Simpson A, Kissen P, Woodcock A, for the NAC Manchester Asthma and Allergy Study Group . Effect of environmental manipulation in pregnancy and early life respiratory symptoms and atopy during first year of life: a randomized trial. Lancet. 2001;358:188–193
  3. Mihrshahi S, Peat JK, Marks GB, Mellis CM, Tovey ER, Webb K, et al. Eighteen-month outcomes of house dust mite avoidance and dietary fatty acid modification in the childhood asthma prevention study (CAPS). J Allergy Clin Immunol. 2003;111:162–168
  4. Peat JK, Mihrshahi S, Kemp A, Marks GB, Tovey ER, Webb K, et al. Three year outcomes of dietary fatty acid modification and house dust mite avoidance in the childhood asthma prevention study (CAPS). J Allergy Clin Immunol. 2004;114:807–813
  5. Horak F, Matthews S, Ihorst G, Arshad SH, Frischer T, Kuehr J, et al. Effect of mite-impermeable encasings and an educational package on the development of allergies in a multinational randomized, controlled birth-cohort study—24 months results of the Study of Prevention of Allergy in children in Europe. Clin Exp Allergy. 2004;34:1220–1225
  6. Chan-Yeung M, Manfreda J, Dimich-Ward H, Ferguson A, Watson W, Becker A. A randomized controlled study on the effectiveness of a multifaceted intervention program in the primary prevention of asthma in high-risk infants. Arch Pediatr Adolesc Med. 2000;154:657–663
  7. Becker A, Watson W, Ferguson A, Dimich-Ward H, Chan-Yeung M. The Canadian asthma primary prevention study: outcomes at 2 years of age. J Allergy Clin Immunol. 2004;113:650–656
  8. Chan-Yeung M, Ferguson A, Dimich-Ward H, Watson W, Manfreda J, Becker A. Effectiveness of intervention measures in reducing allergen levels in a primary prevention of asthma study. Ann Allergy Asthma Immunol. 2002;88:52–58
  9. ISAAC Coordinating Committee . Manual for the International Study of Asthma and Allergies in Childhood (ISAAC). Bochum and Aukland: ISAAC Coordinating Committee; 1992;
  10. Cockcroft DW, Killian DN, Mellon JJ, Hargreave FE. Bronchial reactivity to inhaled histamine: a method and clinical survey. Clin Allergy. 1977;7:235–243
  11. Godfrey S, Springer C, Bar-Yishay E, Avital A. Cut-off points defining normal and asthmatic bronchial reactivity to exercise and inhalation challenges in children and young adults. Eur Respir J. 1999;14:659–668
  12. Pattemore PK, Asher MI, Harrison AC, Mtchell EA, Rea HH, Stewart AW. The interrelationship among bronchial hyperresponsiveness, the diagnosis of asthma and asthma symptoms. Am Rev Respir Dis. 1990;142:549–554
  13. Ernst P, Ghezzo H, Becklake MR. Risk factor for bronchial hyperresponsiveness in late childhood and early adolescence. Eur Respir J. 2002;20:635–639
  14. Hide DW, Matthews S, Matthews L, Stevens M, Ridout S, Twiselton R, et al. Effect of allergen avoidance in infancy on allergic manifestations at age two years. J Allergy Clin Immunol. 1994;93:842–846
  15. Hide DW, Matthews S, Tariq S, Arshad SH. Allergen avoidance in infancy and allergy at 4 years of age. Allergy. 1996;51:89–93
  16. Arshad SH, Bateman B, Matthews SM. Primary prevention of asthma and atopy during childhood by allergen avoidance in infancy: a randomized controlled study. Thorax. 2003;58:489–493
  17. Kurukulaaratchy RJ, Matthews S, Waterhouse L, Arshad SH. Factors influencing symptom expression in children with bronchial hyperresponsiveness at 10 years of age. J Allergy Clin Immunol. 2003;112:311–316

 Supported by the Canadian Institute of Health Research, the British Columbia Lung Association, and the Manitoba Medical Service Foundation.Disclosure of potential conflict of interest: A; authors—none disclosed.

PII: S0091-6749(05)00606-8

doi: 10.1016/j.jaci.2005.03.029

The Journal of Allergy and Clinical Immunology
Volume 116, Issue 1 , Pages 49-55 , July 2005

Article Tools

* Image Usage & Resolution