The Journal of Allergy and Clinical Immunology
Volume 115, Issue 5 , Pages 946-952 , May 2005

Allergen exposure in infancy and the development of sensitization, wheeze, and asthma at 4 years

  • Jessica E. Brussee, MSc

      Affiliations

    • From the Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven
    • Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht
    • ,
  • Henriette A. Smit, PhD

      Affiliations

    • From the Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven
    • Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht
    • Corresponding Author InformationReprint requests: Henriette A. Smit, PhD, National Institute for Public Health and the Environment (RIVM), Center for Prevention and Health Services Research (pigeonhole 101), PO Box 1, 3720 BA Bilthoven, the Netherlands.
    • ,
  • Robert T. van Strien, PhD

      Affiliations

    • Institute for Occupational and Environmental Medicine, Ludwig-Maximilians-University, Munich
    • ,
  • Karen Corver, MD

      Affiliations

    • Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC–Sophia, Rotterdam
    • ,
  • Marjan Kerkhof, MD, PhD

      Affiliations

    • Department of Epidemiology and Statistics, University of Groningen, Groningen
    • ,
  • Alet H. Wijga, PhD

      Affiliations

    • From the Center for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven
    • ,
  • Rob C. Aalberse, PhD

      Affiliations

    • Department of Immunopathology, Sanquin Research at CLB, Amsterdam
    • ,
  • Dirkje Postma, MD, PhD

      Affiliations

    • Department of Pulmonology, University Hospital Groningen, Groningen
    • ,
  • Jorrit Gerritsen, MD, PhD

      Affiliations

    • Department of Paediatric Respiratory Medicine, University Hospital Groningen, Groningen
    • ,
  • Diederick E. Grobbee, MD, PhD

      Affiliations

    • Julius Center for Health Sciences and Primary Care, Utrecht University Medical Center, Utrecht
    • ,
  • Johan C. de Jongste, MD, PhD

      Affiliations

    • Department of Pediatrics, Division of Respiratory Medicine, Erasmus MC–Sophia, Rotterdam
    • ,
  • Bert Brunekreef, PhD

      Affiliations

    • Institute for Risk Assessment Sciences, Utrecht University, Utrecht

Received 18 October 2004 ,Revised 18 February 2005 ,Accepted 24 February 2005.

  • Image Result

    Percentage of children with specific IgE against mite (Der 1), cat (Fel d 1), or dog (Can f 1) by level of allergen exposure. Open columns, Nondetectable allergen exposure; lightly shaded columns, fir

    Percentage of children with specific IgE against mite (Der 1), cat (Fel d 1), or dog (Can f 1) by level of allergen exposure. Open columns, Nondetectable allergen exposure; lightly shaded columns, first tertile of allergen exposure; heavily shaded columns, second tertile of allergen exposure; filled columns, third tertile of allergen exposure. ∗P < .05 compared with nondetectable allergen exposure. ∗∗P < .10 compared with nondetectable allergen exposure.

 Supported by the Netherlands Organisation for Health Research and Development; the Netherlands Organisation for Scientific Research; the Netherlands Asthma Fund; the Netherlands Ministry of Spatial Planning, Housing, and the Environment; and the Netherlands Ministry of Health, Welfare and Sport.Disclosure of potential conflict of interest: All authors—none disclosed.

PII: S0091-6749(05)00527-0

doi: 10.1016/j.jaci.2005.02.035

The Journal of Allergy and Clinical Immunology
Volume 115, Issue 5 , Pages 946-952 , May 2005

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