The Journal of Allergy and Clinical Immunology
Volume 115, Issue 2 , Pages 221-228 , February 2005

Biology of diesel exhaust effects on respiratory function

  • Marc Riedl, MD
  • ,
  • David Diaz-Sanchez, PhD

      Affiliations

    • Corresponding Author InformationReprint requests: David Diaz-Sanchez, PhD, Division of Clinical Immunology/Allergy, Department of Medicine, 52-175 Center for Health Sciences, UCLA School of Medicine, Los Angeles, CA 90095-1680.

Received 22 November 2004 ,Accepted 24 November 2004.

References 

  1. Paramesh H. Epidemiology of asthma in India. Indian J Pediatr. 2002;69:309–312
  2. Hasan MM, Gofin R, Bar-Yishay E. Urbanization and the risk of asthma among schoolchildren in the Palestinian Authority. J Asthma. 2000;37:353–360
  3. Weinberg EG. Urbanization and childhood asthma: an African perspective. J Allergy Clin Immunol. 2000;105:224–231
  4. D'Amato G. Environmental urban factors (air pollution and allergens) and the rising trends in allergic respiratory diseases. Allergy. 2002;57(suppl):30–33
  5. Kagawa J. Health effects of diesel exhaust emissions—a mixture of air pollutants of worldwide concern. Toxicology. 2002;181–182:349–353
  6. Li N, Venkatesan MI, Miguel A, Kaplan R, Gujuluva C, Alam J, et al. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element. J Immunol. 2000;165:3393–3401
  7. Li N, Kim S, Wang M, Froines J, Siouts C, Nel AE. Use of a stratified oxidative stress model to study the biological effects of ambient concentrated and diesel exhaust particulate matter. Inhal Toxicol. 2002;14:459–486
  8. Oberdorster G, Utell MJ. Ultrafine particles in the urban air: to the respiratory tract—and beyond?. Environ Health Perspect. 2002;110:A440–A441
  9. Samet JM, Dominici F, Curriero FC, Coursac I, Zeger SL. Fine particulate air pollution and mortality in 20 U.S. cities, 1987-1994. N Engl J Med. 2000;343:1742–1749
  10. Sarnat JA, Schwartz J, Suh HH. Fine particulate air pollution and mortality in 20 U.S. cities. N Engl J Med. 2001;344:1253–1254
  11. Englert N. Fine particles and human health - a review of epidemiological studies. Toxicol Lett. 2004;149:235–242
  12. Dockery DW, Pope CA, Xu X, Spengler JD, Ware JH, Fay ME, et al. An association between air pollution and mortality in six U.S. cities. N Engl J Med. 1993;329:1753–1759
  13. Schwartz J. Air pollution and children's health. Pediatrics. 2004;113:1037–1043
  14. D'Ippoliti D, Forastiere F, Ancona C, Agabiti N, Fusco D, Michelozzi P, et al. Air pollution and mycardial infarction in Rome: a case-crossover analysis. Epidemiology. 2003;14:528–535
  15. Mann JK, Tager IB, Lurmann F, Segal M, Quesenberry CP, Lugg MM, et al. Air pollution and hospital admissions for ischemic heart disease in persons with congestive heart failure or arrhythmia. Environ Health Perspect. 2002;110:1247–1252
  16. Peters A, Von Klot S, Heier M, Trentinaglia I, Hormann A, Wichmann HE, et al. Exposure to traffic and the onset of myocardial infarction. N Engl J Med. 2004;351:1721–1730
  17. WHO . Health aspects of air pollution with particulate matter, ozone and nitrogen dioxide. Report on a WHO Working Group. Bonn: World Health Organization; 2003;Available at: http://www.euro.who.int/document/e79097.pdfAccessed October 21, 2004
  18. WHO working group. Systematic review of health aspects of air pollution 2003. Available at: www.euro.who.int/document/E82792.pdf and www.euro.who.int/document/E82790.pdf. Accessed October 21, 2004.
  19. US-Environmental Protection Agency . Air quality criteria for particulate matter. Chapel Hill (NC): Environmental Protection Agency; 2003;
  20. Gluck U, Schutz R, Gebbers JO. Cytopathology of the nasal mucosa in chronic exposure to diesel engine emission: a five-year survey of Swiss customs officers. Environ Health Perspect. 2003;111:925–929
  21. Mastrangelo G, Clonfero E, Pavanello S, Fedeli U, Fadda E, Turato A, et al. Exposure to diesel exhaust enhances total IgE in non-atopic dockers. Int Arch Occup Environ Health. 2003;76:63–68
  22. Marr LC, Grogan LA, Wohrnschimmel H, Molina LT, Molina MJ, Smith TJ, et al. Vehicle traffic as a source of particulate polycyclic aromatic hydrocarbon exposure in the Mexico City metropolitan area. Environ Sci Technol. 2004;38:2584–2592
  23. Burnett RT, Dales RE, Raizenne ME, Krewski D, Summers PW, Roberts GR, et al. Effects of low ambient levels of ozone and sulfates on the frequency of respiratory admissions to Ontario hospitals. Environ Res. 1994;65:172–194
  24. Wjst M, Reitmeir P, Dold S, Wulff A, Nicolai T, von Loeffelholz-Colberg EF, et al. Road traffic and adverse effects on respiratory health in children. BMJ. 1993;307:596–600
  25. Braun-Fahrlander C, Vuille JC, Sennhauser FH, Neu U, Kunzle T, Grize L, et al. Respiratory health and long-term exposure to air pollutants in Swiss schoolchildren. SCARPOL Team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution, Climate and Pollen. Am J Respir Crit Care Med. 1997;155:1042–1049
  26. Dockery DW, Speizer FE, Stram DO, Ware JH, Spengler JD, Ferris BG. Effects of inhalable particles on respiratory health of children. Am Rev Respir Dis. 1989;139:587–594
  27. Shima M, Nitta Y, Adachi M. Traffic-related air pollution and respiratory symptoms in children living along trunk roads in Chiba Prefecture, Japan. J Epidemiol. 2003;13:108–119
  28. Brauer M, Hoek G, Van Vliet P, Meliefste K, Fischer PH, Wijga A, et al. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. Am J Respir Crit Care Med. 2002;166:1092–1098
  29. Venn AJ, Lewis SA, Cooper M, Hubbard R, Britton J. Living near a main road and the risk of wheezing illness in children. Am J Respir Crit Care Med. 2001;164:2177–2180
  30. Duhme H, Weiland SK, Keil U, Kraemer B, Schmid M, Stender M, et al. The association between self-reported symptoms of asthma and allergic rhinitis and self-reported traffic density on street of residence in adolescents. Epidemiology. 1996;7:578–582
  31. Lin S, Munsie JP, Hwang SA, Fitzgerald E, Cayo MR. Childhood asthma hospitalization and residential exposure to state route traffic. Environ Res. 2002;88:73–81
  32. Zmirou D, Gauvin S, Pin I, Momas I, Sahraoui F, Just J, et al. Traffic related air pollution and incidence of childhood asthma: results of the Vesta case-control study. J Epidemiol Community Health. 2004;58:18–23
  33. Edwards J, Walters S, Griffiths RK. Hospital admissions for asthma in preschool children: relationship to major roads in Birmingham, United Kingdom. Arch Environ Health. 1994;49:223–227
  34. van Vliet P, Knape M, de Hartog J, Janssen N, Harssema H, Brunekreef B. Motor vehicle exhaust and chronic respiratory symptoms in children living near freeways. Environ Res. 1997;74:122–132
  35. Edwards J, Walter S, Griffiths RK. Hospital admissions for asthma in preschool children: relationship to major roads in Birmingham, United Kingdom. Arch Environ Health. 1994;49:223–227
  36. Kramer U, Koch T, Ranft U, Ring J, Behrendt H. Traffic-related air pollution is associated with atopy in children living in urban areas. Epidemiology. 2000;11:64–70
  37. Janssen NAH, Brunekreef B, Van Vliet P, Aarts F, Meliesfste K, Harssema H. The relationship between air pollution from heavy traffic and allergic sensitization, bronchial hyperresponsiveness, and respiratory symptoms in Dutch schoolchildren. Environ Health Perspect. 2003;111:1512–1518
  38. Braback L, Breborowicz A, Dreborg S, Knutsson A, Pieklik H, Bjorksten B. Atopic sensitization and respiratory symptoms among Polish and Swedish school children. Clin Exp Allergy. 1994;24:826–835
  39. Wyler C, Braun-Fahrlander C, Kunzli N, Schindler C, Ackermann-Liebrich U, Perruchoud AP, et al. Exposure to motor vehicle traffic and allergic sensitization. Epidemiology. 2000;11:450–456
  40. Nel AE, Diaz-Sanchez D, Ng D, Hiura T, Saxon A. Enhancement of allergic inflammation by the interaction between diesel exhaust particles and the immune system. J Allergy Clin Immunol. 1998;102:539–554
  41. Muranaka M, Suzuki S, Koizumi K, Takafuji S, Miyamoto T, Ikemori R, et al. Adjuvant activity of diesel-exhaust particulates for the production of IgE antibody in mice. J Allergy Clin Immunol. 1986;77:616–623
  42. Takano H, Yoshikawa T, Ichinose T, Miyabara Y, Imaoka K, Sagai M. Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice. Am J Respir Crit Care Med. 1997;156:36–42
  43. Miyabara Y, Ichinose T, Takano H, Lim HB, Sagai M. Effects of diesel exhaust on allergic airway inflammation in mice. J Allergy Clin Immunol. 1998;102:805–812
  44. Ichinose T, Takano H, Miyabara Y, Sadakaneo K, Sagai M, Shibamoto T. Enhancement of antigen-induced eosinophilic inflammation in the airways of mast-cell deficient mice by diesel exhaust particles. Toxicology. 2002;180:293–301
  45. Ohta K, Yamashita N, Tajima M, Miyasaka T, Nakano J, Nakajima M, et al. Diesel exhaust particulate induces airway hyperresponsiveness in a murine model: essential role of GM- CSF. J Allergy Clin Immunol. 1999;104:1024–1030
  46. Sagai M, Furuyama A, Ichinose T. Biological effects of diesel exhaust particles (DEP). III. Pathogenesis of asthma like symptoms in mice. Free Radic Biol Med. 1996;21:199–209
  47. Pereira P, Saldiva PH, Sakae RS, Bohm GM, Martins MA. Urban levels of air pollution increase lung responsiveness in rats. Environ Res. 1995;69:96–101
  48. Steerenberg PA, Dormans JA, van Doorn CC, Middendorp S, Vos JG, van Loveren H. A pollen model in the rat for testing adjuvant activity of air pollution components. Inhal Toxicol. 1999;11:1109–1122
  49. Kobayashi T. Exposure to diesel exhaust aggravates nasal allergic reaction in guinea pigs. Am J Respir Crit Care Med. 2000;162:352–356
  50. Kobayashi T, Ikeue T, Ikeda A. Four-week exposure to diesel exhaust induces nasal mucosal hyperresponsiveness to histamine in guinea pigs. Toxicol Sci. 1998;45:106–112
  51. Takenaka H, Zhang K, Diaz-Sanchez D, Tsien A, Saxon A. Enhanced human IgE production results from exposure to the aromatic hydrocarbons from diesel exhaust: direct effects on B- cell IgE production. J Allergy Clin Immunol. 1995;95:103–115
  52. Terada N, Hamano N, Maesako KI, Hiruma K, Hohki G, Suzuki K, et al. Diesel exhaust particulates upregulate histamine receptor mRNA and increase histamine-induced IL-8 and GM-CSF production in nasal epithelial cells and endothelial cells. Clin Exp Allergy. 1999;29:52–59
  53. Terada N, Maesako K, Hiruma K, Hamano N, Houki G, Konno A, et al. Diesel exhaust particulates enhance eosinophil adhesion to nasal epithelial cells and cause degranulation. Int Arch Allergy Immunol. 1997;114:167–174
  54. Fahy O, Hammad H, Senechal S, Pestel J, Tonnel AB, Wallaert B, et al. Synergistic effect of diesel organic extracts and allergen Der p 1 on the release of chemokines by peripheral blood mononuclear cells from allergic subjects: involvement of the map kinase pathway. Am J Respir Cell Mol Biol. 2000;23:247–254
  55. Chanez P, Enander I, Jones I, Godard P, Bousquet J. Interleukin 8 in bronchoalveolar lavage of asthmatic and chronic bronchitis patients. Int Arch Allergy Immunol. 1996;111:83–88
  56. Alam R, York J, Boyars M, Stafford S, Grant JA, Lee J, et al. Increased MCP-1, RANTES, and MIP-1alpha in bronchoalveolar lavage fluid of allergic asthmatic patients. Am J Respir Crit Care Med. 1996;153:1398–1404
  57. Bayram H, Devalia JL, Khair OA, Abdelaziz MM, Sapsford RJ, Sagai M, et al. Comparison of ciliary activity and inflammatory mediator release from bronchial epithelial cells of nonatopic nonasthmatic subjects and atopic asthmatic patients and the effect of diesel exhaust particles in vitro. J Allergy Clin Immunol. 1998;102:771–782
  58. Diaz-Sanchez D, Jyrala M, Ng D, Nel A, Saxon A. In vivo nasal challenge with diesel exhaust particles enhances expression of the CC chemokines rantes, MIP-1alpha, and MCP-3 in humans. Clin Immunol. 2000;97:140–145
  59. Salvi S, Blomberg A, Rudell B, Kelly F, Sandstrom T, Holgate ST, et al. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med. 1999;159:702–709
  60. Salvi SS, Nordenhall C, Blomberg A, Rudell B, Pourazar J, Kelly FJ, et al. Acute exposure to diesel exhaust increases IL-8 and GRO-alpha production in healthy human airways. Am J Respir Crit Care Med. 2000;161:550–557
  61. Stenfors N, Nordenhall C, Salvi SS, Mudway I, Soderberg M, Blomberg A, et al. Different airway inflammatory responses in asthmatic and healthy humans exposed to diesel. Eur Respir J. 2004;23:82–86
  62. Nordenhall C, Pourazar J, Blomberg A, Levin JO, Sandstrom T, Adelroth E. Airway inflammation following exposure to diesel exhaust: a study of time kinetics using induced sputum. Eur Respir J. 2000;15:1046–1051
  63. Nordenhall C, Pourazar J, Ledin MC, Levin JO, Sandstrom T, Adelroth E. Diesel exhaust enhances airway responsiveness in asthmatic subjects. Eur Respir J. 2001;17:909–915
  64. Rudell B, Ledin MC, Hammarstrom U, Stjernberg N, Lundback B, Sandstrom T. Effects on symptoms and lung function in humans experimentally exposed to diesel exhaust. Occup Environ Med. 1996;53:658–662
  65. Diaz-Sanchez D, Tsien A, Fleming J, Saxon A. Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern. J Immunol. 1997;158:2406–2413
  66. Fujieda S, Diaz-Sanchez D, Saxon A. Combined nasal challenge with diesel exhaust particles and allergen induces in vivo IgE isotype switching. Am J Respir Cell Mol Biol. 1998;19:507–512
  67. Diaz-Sanchez D, Dotson AR, Takenaka H, Saxon A. Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms. J Clin Invest. 1994;94:1417–1425
  68. Devouassoux G, Saxon A, Metcalfe DD, Prussin C, Colomb MG, Brambilla C, et al. Chemical constituents of diesel exhaust particles induce IL-4 production and histamine release by human basophils. J Allergy Clin Immunol. 2002;109:847–853
  69. Nemmar A, Hoet PH, Vermylen J, Nemery B, Hoylaerts MF. Pharmacological stabilization of mast cells abrogates late thrombotic events induced by diesel exhaust particles in hamsters. Circulation. 2004;110:1670–1677
  70. Diaz-Sanchez D, Penichet-Garcia M, Saxon A. Diesel exhaust particles directly induce activated mast cells to degranulate and increase histamine levels and symptom severity. J Allergy Clin Immunol. 2000;106:1140–1146
  71. Diaz-Sanchez D, Garcia MP, Wang M, Jyrala M, Saxon A. Nasal challenge with diesel exhaust particles can induce sensitization to a neoallergen in the human mucosa. J Allergy Clin Immunol. 1999;104:1183–1188
  72. Madden MC, Dailey LA, Stonehuerner JG, Harris BD. Responses of cultured human airway epithelial cells treated with diesel exhaust extracts will vary with the engine load. J Toxicol Environ Health A. 2003;66:2281–2297
  73. Bowler RP, Crapo JD. Oxidative stress in allergic respiratory diseases. J Allergy Clin Immunol. 2002;110:349–356
  74. Sanders SP, Zweier JL, Harrison SJ, Trush MA, Rembish SJ, Liu MC. Spontaneous oxygen radical production at sites of antigen challenge in allergic subjects. Am J Respir Crit Care Med. 1995;151:1725–1733
  75. Stevens WH, Inman MD, Wattie J, O'Byrne PM. Allergen-induced oxygen radical release from bronchoalveolar lavage cells and airway hyperresponsiveness in dogs. Am J Respir Crit Care Med. 1995;151:1526–1531
  76. Lansing MW, Ahmed A, Cortes A, Sielczak MW, Wanner A, Abraham WM. Oxygen radicals contribute to antigen-induced airway hyperresponsiveness in conscious sheep. Am Rev Respir Dis. 1993;147:321–326
  77. Rahman Q, Abidi P, Afaq F, Schiffmann D, Mossman BT, Kamp DW, et al. Glutathione redox system in oxidative lung injury. Crit Rev Toxicol. 1999;29:543–568
  78. Horvath I, Donnelly LE, Kiss A, Paredi P, Kharitonov SA, Barnes PJ. Raised levels of exhaled carbon monoxide are associated with an increased expression of heme oxygenase-1 in airway macrophages in asthma: a new marker of oxidative stress. Thorax. 1998;53:668–672
  79. Silkoff PE, Robbins RA, Gaston B, Lundberg JO, Townley RG. Endogenous nitric oxide in allergic airway disease. J Allergy Clin Immunol. 2000;105:438–448
  80. Emelyanov A, Fedoseev G, Abulimity A, Rudinski K, Fedoulov A, Karabanov A, et al. Elevated concentrations of exhaled hydrogen peroxide in asthmatic patients. Chest. 2001;120:1136–1139
  81. Montuschi P, Corradi M, Ciabattoni G, Nightingale J, Kharitonov SA, Barnes PJ. Increased 8-isoprostane, a marker of oxidative stress, in exhaled condensate of asthma patients. Am J Respir Crit Care Med. 1999;160:216–220
  82. Hulsmann AR, Raatgeep HR, den Hollander JC, Stijnen T, Saxena PR, Kerrebijn KF, et al. Oxidative epithelial damage produces hyperresponsiveness of human peripheral airways. Am J Respir Crit Care Med. 1994;149:519–525
  83. Powell CV, Nash AA, Powers HJ, Primhak RA. Antioxidant status in asthma. Pediatr Pulmonol. 1994;18:34–38
  84. Kinnula VL, Crapo JD. Superoxide dismutases in the lung and human lung diseases. Am J Respir Crit Care Med. 2003;167:1600–1619
  85. Hiura TS, Kaszubowski MP, Li N, Nel AE. Chemicals in diesel exhaust particles generate reactive oxygen radicals and induce apoptosis in macrophages. J Immunol. 1999;163:5582–5591
  86. Li N, Wang M, Oberley TD, Sempf JM, Nel AE. Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages. J Immunol. 2002;169:4531–4541
  87. Arimoto T, Yoshikawa T, Takano H, Kohno M. Generation of reactive oxygen species and 8-hydroxy-2′-deoxyguanosine formation from diesel exhaust particle components in L1210 cells. Jpn J Pharmacol. 1999;80:49–54
  88. Takano H, Yoshikawa T, Ichinose T, Miyabara Y, Imaoka K, Sagai M. Diesel exhaust particles enhance antigen-induced airway inflammation and local cytokine expression in mice. Am J Respir Crit Care Med. 1997;156:36–42
  89. Lim HB, Ichinose T, Miyabara Y, Takano H, Kumagai Y, Shimojyo N, et al. Involvement of superoxide and nitric oxide on airway inflammation and hyperresponsiveness induced by diesel exhaust particles in mice. Free Radic Biol Med. 1998;25:635–644
  90. Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, et al. Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization. J Immunol. 2002;168:2560–2567
  91. Gurgueira SA, Lawrence J, Coull B, Murthy GG, Gonzalez-Flecha B. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environ Health Perspect. 2002;110:749–755
  92. Nightingale JA, Maggs R, Cullinan P, Donnelly LE, Rogers DF, Kinnersley R, et al. Airway inflammation after controlled exposure to diesel exhaust particulates. Am J Respir Crit Care Med. 2000;162:161–166
  93. Dworski R, Roberts LJ, Murray JJ, Morrow JD, Hartert TV, Sheller JR. Assessment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2- isoprostane, 15-F2t-IsoP (8-iso-PGF2alpha). Clin Exp Allergy. 2001;31:387–390
  94. Baulig A, Sourdeval M, Meyer M, Marano F, Baeza-Squiban A. Biological effects of atmospheric particles on human bronchial epithelial cells. Comparison with diesel exhaust particles. Toxicol In Vitro. 2003;17:567–573
  95. Li N, Hao M, Phalen RF, Hinds WC, Nel AE. Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects. Clin Immunol. 2003;109:250–265
  96. Takizawa H, Ohtoshi T, Kawasaki S, Kohyama T, Desaki M, Kasama T, et al. Diesel exhaust particles induce NF-kappa B activation in human bronchial epithelial cells in vitro: importance in cytokine transcription. J Immunol. 1999;162:4705–4711
  97. Ng D, Kokot N, Hiura T, Faris M, Saxon A, Nel A. Macrophage activation by polycyclic aromatic hydrocarbons: evidence for the involvement of stress-activated protein kinases, activator protein-1, and antioxidant response elements. J Immunol. 1998;161:942–951
  98. Jiminez LA, Thomson J, Brown D. PM10 particles activate NFκB in alveolar epithelial cells. [abstract] Am J Respir Crit Care Med. 1999;159:A27
  99. Takizawa H, Ohtoshi T, Kawasaki S, Kohyama T, Desaki M, Kasama T, et al. Diesel exhaust particles induce NF-kappa B activation in human bronchial epithelial cells in vitro: importance in cytokine transcription. J Immunol. 1999;162:4705–4711
  100. Pandya RJ, Solomon G, Kinner A, Balmes JR. Diesel exhaust and asthma: hypotheses and molecular mechanisms of action. Environ Health Perspect. 2002;110(suppl 1):103–112
  101. Takizawa H, Abe S, Okazaki H, Kohyama T, Sugawara I, Saito Y, et al. Diesel exhaust particles upregulate eotaxin gene expression in human bronchial epithelial cells via nuclear factor-kappa B-dependent pathway. Am J Physiol Lung Cell Mol Physiol. 2003;284:L1055–L1062
  102. Hashimoto S, Gon Y, Takeshita I, Matsumoto K, Jibiki I, Takizawa H, et al. Diesel exhaust particles activate p38 MAP kinase to produce interleukin 8 and RANTES by human bronchial epithelial cells and N-acetylcysteine attenuates p38 MAP kinase activation. Am J Respir Crit Care Med. 2000;161:280–285
  103. Finkelman FD, Yang M, Orekhova T, Clyne E, Bernstein J, Whitekus M, et al. Diesel exhaust particles inhibit Interferon-γ production by inhibiting cytokine effects on NK and NKT cells. J Immunol. 2004;172:3808–3813
  104. Knox RB, Suphioglu C, Taylor P, Desai R, Watson HC, Peng JL, et al. Major grass pollen allergen Lol p 1 binds to diesel exhaust particles: implications for asthma and air pollution. Clin Exp Allergy. 1997;27:246–251
  105. Li N, Sioutas C, Cho A, Schmitz D, Misra C, Sempf J, et al. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ Health Perspect. 2003;111:455–460
  106. Gilliland FD, Li YF, Saxon A, Diaz-Sanchez D. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo- controlled crossover study. Lancet. 2004;363:119–125
  107. Ivaschenko TE, Sideleva OG, Baranov VS. Glutathione-S-transferase micro and theta gene polymorphisms as new risk factors of atopic bronchial asthma. J Mol Med. 2002;80:39–43
  108. Fryer AA, Bianco A, Hepple M, Jones PW, Strange RC, Spiteri MA. Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma. Am J Respir Crit Care Med. 2000;161:1437–1442
  109. Spiteri MA, Bianco A, Strange RC, Fryer AA. Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation. Allergy. 2000;55(suppl 61):15–20
  110. Gilliland FD, Gauderman WJ, Vora H, Rappaport E, Dubeau L. Effects of glutathione-S- transferase M1, T1, and P1 on childhood lung function growth. Am J Respir Crit Care Med. 2002;166:710–716
  111. Pearson PJ, Lewis SA, Britton J, Fogarty A. Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial. Thorax. 2004;59:652–656
  112. Fogarty A, Lewis SA, Scrivener SL, Antoniak M, Pacey S, Pringle M, et al. Oral magnesium and vitamin C supplements in asthma: a parallel group randomized placebo- controlled trial. Clin Exp Allergy. 2003;33:1355–1359
  113. Allam MF, Lucane RA. Selenium supplementation for asthma. Cochrane Database Syst Rev. 2004;2:CD003538
  114. Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, Moreno-Macias H, Reyes-Ruiz NI, Estela del Rio-Navarro B, et al. Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City. Thorax. 2004;59:8–10

 Series editors: William T. Shearer, MD, PhD, Lanny J. Rosenwasser, MD, and Bruce S. Bochner, MDSupported by the UCLA Allergy, Asthma, and Immunologic Disease Center (grant AI-40945) funded by the National Institute of Allergy and Infectious Diseases and the National Institute of Environmental Health Sciences.Disclosure of potential conflict of interest: M. Riedl—none disclosed. D. Diaz-Sanchez—none disclosed.

PII: S0091-6749(04)03223-3

doi: 10.1016/j.jaci.2004.11.047

The Journal of Allergy and Clinical Immunology
Volume 115, Issue 2 , Pages 221-228 , February 2005