The Journal of Allergy and Clinical Immunology
Volume 113, Issue 1 , Pages 115-119 , January 2004

Anti–interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes

  • Jennifer K Garrett, PA-C

      Affiliations

    • Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
    • ,
  • Sean C Jameson, BA

      Affiliations

    • Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
    • ,
  • Blythe Thomson, MD

      Affiliations

    • Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
    • ,
  • Margaret H Collins, MD

      Affiliations

    • Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
    • ,
  • Lynne E Wagoner, MD

      Affiliations

    • Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    • ,
  • Debbie K Freese, MD

      Affiliations

    • Department of Pediatrics, Mayo Clinic and Foundation, Rochester, Minn, USA
    • ,
  • Lisa A Beck, MD

      Affiliations

    • Department of Medicine, Johns Hopkins Asthma and Allergy Center, Johns Hopkins School of Medicine, Baltimore, Md, USA
    • ,
  • Joshua A Boyce, MD

      Affiliations

    • Department of Medicine, Brigham and Women's Hospital, Department of Pediatrics, Massachusetts General Hospital, Boston, Mass, USA
    • ,
  • Alexandra H Filipovich, MD

      Affiliations

    • Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
    • ,
  • Joyce M Villanueva, BS

      Affiliations

    • Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
    • ,
  • Steven A Sutton, MD

      Affiliations

    • Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
    • ,
  • Amal H Assa'ad, MD

      Affiliations

    • Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
    • ,
  • Marc E Rothenberg, MD, PhD

      Affiliations

    • Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA
    • Corresponding Author InformationReprint requests: Dr Marc E. Rothenberg, Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7028, Cincinnati, OH 45229

Received 11 October 2003 ,Revised 20 October 2003 ,Accepted 12 December 2003.

References 

    References
  1. Weller PF. The idiopathic hypereosinophilic syndrome. Blood. 1994;83:2759–2779
  2. Assa'ad AH, Spicer RL, Nelson DP, Zimmermann N, Rothenberg ME. Hypereosinophilic syndromes. Chem Immunol. 2000;76:208–229
  3. Roufosse F, Cogan E, Goldman M. The hypereosinophilic syndrome revisited. Annu Rev Med. 2003;54:169–184
  4. Rothenberg ME. Eosinophilic gastrointestinal disorders (EGID). J Allergy Clin Immunol. 2004;113:11–28
  5. Fox VL, Nurko S, Furuta GT. Eosinophilic esophagitis: it's not just kid's stuff. Gastrointest Endosc. 2002;56:260–270
  6. Gleich GJ. Mechanisms of eosinophil-associated inflammation. J Allergy Clin Immunol. 2000;105:651–663
  7. Hamelmann E, Gelfand EW. IL-5-induced airway eosinophilia: the key to asthma?. Immunol Rev. 2001;179:182–191
  8. Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, et al.  Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet. 2000;356:2144–2148
  9. Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS. Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med. 2003;167:199–204
  10. Kips JC, O'Connor BJ, Langley SJ, Woodcock AA, Kerstjens HA, Postma DS, et al.  Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. Am J Respir Crit Care Med. 2003;167:1655–1659
  11. Owen WF, Rothenberg ME, Petersen J, Weller PF, Silberstein D, Sheffer AL, et al.  Interleukin 5 and phenotypically altered eosinophils in the blood of patients with the idiopathic hypereosinophilic syndrome. J Exp Med. 1989;170:343–348
  12. Straumann A, Bauer M, Fischer B, Blaser K, Simon HU. Idiopathic eosinophilic esophagitis is associated with a T(H)2-type allergic inflammatory response. J Allergy Clin Immunol. 2001;108:954–961
  13. Mishra A, Hogan SP, Brandt EB, Rothenberg ME. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest. 2001;107:83–90
  14. Gleich GJ, Leiferman KM, Pardanani A, Tefferi A, Butterfield JH. Treatment of hypereosinophilic syndrome with imatinib mesilate. Lancet. 2002;359:1577–1578
  15. Cools J, DeAngelo DJ, Gotlib J, Stover EH, Legare RD, Cortes J, et al.  A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med. 2003;348:1201–1214
  16. Ware JE, Snow KK, Kosinski M. SF-36 Health Survey: Manual and Interpretation Guide. Lincoln (RI): Quality Metric Incorporated; 2000;

☆ Supported in part by the Burroughs Wellcome Fund and the NIH-supported Clinical Research Center and the Translational Research Office at Cincinnati Children's Hospital Medical Center.

PII: S0091-6749(03)02533-8

doi: 10.1016/j.jaci.2003.10.049

The Journal of Allergy and Clinical Immunology
Volume 113, Issue 1 , Pages 115-119 , January 2004

Article Tools

* Image Usage & Resolution