The Journal of Allergy and Clinical Immunology
Volume 113, Issue 1 , Page 10, January 2004

Verdict in the case of therapies versus eosinophils:

The jury is still out

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Instructions for category 1 continuing medical education credit 

The American Academy of Allergy, Asthma and Immunology is accredited as a provider of Continuing Medical Education (CME) by the Accreditation Council for Continuing Medical Education.

Test ID no.: mai0025

Contact hours: 1.0

Expiration date: December 31, 2004

Category 1 credit can be earned by reading the text material and taking this CME examination online. For complete instructions, visit the Journal's Web site at www.mosby.com/jaci.

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Learning objectives: “Verdict in the case of therapies versus eosinophils: the jury is still out” 

1.To review the potential role of eosinophils in asthma and allergic diseases.

2.To discuss both eosinophil-specific and eosinophil-selective therapies in the context of the surface phenotype of human eosinophils.

3.To review the known and theoretical benefits and risks of such treatments.

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CME items 

Question 1.Which adhesion molecule is expressed on eosinophils, basophils, and T lymphocytes but not on neutrophils?
A.L-selectin (CD62L)

B.PSGL-1 (CD162)

C.VLA-4 (CD49d/CD29)

D.LFA-1 (CD11a/CD18)


Question 2.A drug that blocks eosinophil migratory responses to prostaglandin D2 would antagonize which one of the following receptors?
A.CCR3

B.CRTH2

C.LIR-7

D.CysLT1


Question 3.When tested in human beings, anti–IL-5 antibody infusions prevented allergen-induced …
A.increases in sputum eosinophil numbers.

B.acute reductions in FEV1.

C.late-phase reductions in FEV1.

D.bronchial hyperreactivity.


Question 4.Incubation with antibodies to Siglec-8, an inhibitory molecule found on eosinophils, has been shown to reduce which one of the following responses?
A.degranulation

B.migration

C.leukotriene generation

D.survival


PII: S0091-6749(03)02441-2

doi:10.1016/j.jaci.2003.10.006

The Journal of Allergy and Clinical Immunology
Volume 113, Issue 1 , Page 10, January 2004

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