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The Journal of Allergy and Clinical Immunology
Volume 111, Issue 1
, Pages 38-44
, January 2003
Unraveling the mission of FcϵRI on antigen-presenting cells
References
- . The high-affinity IgE receptor (Fc epsilon RI): from physiology to pathology. Annu Rev Immunol. 1999;17:931–972
- . Diagnostic criteria for atopic dermatitis: consider the context. Arch Dermatol. 1999;135:1551
- . IgE-positive Langerhans cells and Th2 allergen-specific T cells in atopic dermatitis. J Invest Dermatol. 1992;99:103S
- . Human kera-tinocytes release the endogenous beta-galactoside-binding soluble lectin immunoglobulin E (IgE-binding protein) which binds to Langerhans cells where it modulates their binding capacity for IgE glycoforms. J Exp Med. 1993;178:777–785
- Human epidermal langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI). J Exp Med. 1992;175:1285–1290
- Epidermal langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI. J Exp Med. 1992;175:1353–1365
- Expression of functional high affinity immunoglobulin E receptors (Fc epsilon RI) on monocytes of atopic individuals. J Exp Med. 1994;179:745–750
- Immunomorphologic characterization of Fc epsilon RI-bearing cells within the human dermis. J Invest Dermatol. 1994;102:315–320
- Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. J Immunol. 1996;157:607–616
- . Structure of the human IgE-Fc C epsilon 3-C epsilon 4 reveals conformational flexibility in the antibody effector domains. Immunity. 2000;13:375–385
- . A second amplifier function for the allergy-associated Fc(epsilon)RI-beta subunit. Immunity. 2000;12:515–523
- . The Fc(epsilon)RIbeta subunit functions as an amplifier of Fc(epsilon)RIgamma-mediated cell activation signals. Cell. 1996;85:985–995
- . Expression of high-affinity binding of human immunoglobulin E by transfected cells. Science. 1989;244:334–337
- Fc epsilon RI mediates IgE binding to human epidermal langerhans cells. J Invest Dermatol. 1992;99:30S–32S
-
.
A reducing microenvironment leads to the generation of FcϵRI high inflammatory dendritic epidermal cells (IDEC).
J Invest Dermatol. 2002;
In press
- Phenotyping of epidermal dendritic cells allows the differentiation between extrinsic and intrinsic forms of atopic dermatitis. Br J Dermatol. 2000;143:1193–1198
- . Langerhans cell phenotyping: a new tool for differential diagnosis of inflammatory skin diseases. Lancet. 1995;346:1626–1627
- . Regulation of the high affinity receptor for IgE on human epidermal langerhans cells. J Immunol. 1998;161:1000–1006
- . Glycosylation of human truncated Fc epsilon RI alpha chain is necessary for efficient folding in the endoplasmic reticulum. J Biol Chem. 1995;270:8249–8256
- . Export of the high affinity IgE receptor from the endoplasmic reticulum depends on a glycosylation-mediated quality control mechanism. J Immunol. 2000;165:5686–5694
- . Minimal requirements for IgE-mediated regulation of surface Fc epsilon RI. J Immunol. 2001;167:1290–1296
- Fc epsilon receptor I on dendritic cells delivers IgE-bound multivalent antigens into a cathepsin S-dependent pathway of MHC class II presentation. J Immunol. 1998;161:2731–2739
- . Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects. J Immunol. 2001;167:1734–1739
- . Role of aeroallergens in atopic eczema: proof of concept with the atopy patch test. J Am Acad Dermatol. 2001;45(suppl 1):S49–S52
-
.
The role of the atopy patch test (APT) in diagnosis of food allergy in infants and children with atopic dermatitis.
Pediatr Allergy Immunol. 2001;12(suppl 14):37–40
- . The involvement of eosinophils in the patch test reaction to aeroallergens in atopic dermatitis: its relevance for the pathogenesis of atopic dermatitis. Clin Exp Allergy. 1993;23:97–109
- Clinical and immunologic variables in skin of patients with atopic eczema and either positive or negative atopy patch test reactions. J Allergy Clin Immunol. 2000;105:1008–1016
- . Atopy patch test reactions are associated with T lymphocyte-mediated allergen-specific immune responses in atopic dermatitis. Clin Exp Allergy. 1999;29:513–521
- . Evaluating the relevance of aeroallergen sensitization in atopic eczema with the atopy patch test: a randomized, double-blind multicenter study. Atopy Patch Test Study Group J Am Acad Dermatol. 1999;40:187–193
- . Activation of human epidermal langerhans cells by engagement of the high affinity receptor for IgE, Fc epsilon RI. J Immunol. 1995;155:5184–5189
-
.
Enhanced expression and activity of protein-tyrosine kinase establishes a functional signaling pathway in FcϵRI Langerhans cells.
J Invest Dermatol. 2002;
In press
- . Aggregation of the high-affinity IgE receptor Fc(epsilon)RI on human monocytes and dendritic cells induces NF-kappaB activation. J Invest Dermatol. 2002;118:830–837
- Role of the high affinity immunoglobulin E receptor in bacterial translocation and intestinal inflammation. J Exp Med. 2001;193:25–34
- Engagement of the Fc epsilon RI stimulates the production of IL-16 in Langerhans cell-like dendritic cells. J Immunol. 2001;167:6321–6329
- . Engagement of FcepsilonRI on human monocytes induces the production of IL-10 and prevents their differentiation in dendritic cells. J Immunol. 2001;167:797–804
- Regulation of mast cell survival by IgE. Immunity. 2001;14:791–800
- Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity. 2001;14:801–811
- . The high-affinity IgE receptor (FcepsilonRI) blocks apoptosis in normal human monocytes. J Clin Invest. 2000;105:183–190
- . Topical tacrolimus (FK506) leads to profound phenotypic and functional alterations of epidermal antigen-presenting dendritic cells in atopic dermatitis. J Allergy Clin Immunol. 2001;107:519–525
- . Human epidermal Langerhans' cells are targets for the immunosuppressive macrolide tacrolimus (FK506). J Allergy Clin Immunol. 2001;107:345–352
- . To bend or not to bend. Nat Immunol. 2002;3:607–608
- . Anti-IgE treatment: an update. Allergy. 2001;56:1121–1128
- . Immunology. Giving inhibitory receptors a boost. Science. 2001;291:445–446
- . Signaling through the high-affinity IgE receptor Fc epsilon RI. Nature. 1999;402:B24–B30
- . Immunologically mediated signaling in basophils and mast cells: finding therapeutic targets for allergic diseases in the human FcvarepsilonR1 signaling pathway. Immunopharmacology. 2000;48:269–281
- . Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase. J Exp Med. 2002;196:459–468
- FcespilonRI induces the tryptophan degradation pathway involved in the regulation of T-cell responses. J Immunol. 2002;169:1810–1816
☆ Reprint requests: Natalija Novak, MD, Department of Dermatology, Friedrich-Wilhelms-University, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany.
PII: S0091-6749(02)91264-9
doi: 10.1067/mai.2003.2
© 2003 Mosby, Inc. All rights reserved.
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The Journal of Allergy and Clinical Immunology
Volume 111, Issue 1
, Pages 38-44
, January 2003
