The Journal of Allergy and Clinical Immunology
Volume 110, Issue 5 , Pages 736-742 , November 2002

A longitudinal analysis of wheezing in young children: The independent effects of early life exposure to house dust endotoxin, allergens, and pets

  • Augusto A. Litonjua, MD, MPH

      Affiliations

    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital Boston, Mass
    • the Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center Boston, Mass
    • Harvard Medical School Boston, Mass
    • ,
  • Donald K. Milton, MD, DrPH

      Affiliations

    • Harvard School of Public Health Boston, Mass
    • ,
  • Juan C. Celedon, MD, DrPH

      Affiliations

    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital Boston, Mass
    • the Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center Boston, Mass
    • Harvard Medical School Boston, Mass
    • ,
  • Louise Ryan, PhD

      Affiliations

    • Harvard School of Public Health Boston, Mass
    • the Dana-Farber Cancer Institute, Boston. Boston, Mass
    • ,
  • Scott T. Weiss, MD, MS

      Affiliations

    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital Boston, Mass
    • Harvard Medical School Boston, Mass
    • Harvard School of Public Health Boston, Mass
    • ,
  • Diane R. Gold, MD,MPH

      Affiliations

    • Channing Laboratory, Department of Medicine, Brigham and Women's Hospital Boston, Mass
    • the Division of Pulmonary and Critical Care Medicine, Beth Israel Deaconess Medical Center Boston, Mass
    • Harvard Medical School Boston, Mass
    • Harvard School of Public Health Boston, Mass

Received 8 January 2002 ,Revised 26 July 2002 ,Accepted 9 August 2002.

  • Image Result

    Proportions of children with wheezing at each of the follow-up time points with respect to HDE exposure. *P = .006 for the difference between 2 groups at 14 months of follow-up.

    Proportions of children with wheezing at each of the follow-up time points with respect to HDE exposure. *P = .006 for the difference between 2 groups at 14 months of follow-up.

☆ Supported by US National Institute of Allergy and Infectious Disease grant RO1 AI/EHS-35786 and National Institute for Environmental Health Science grant RO1 ES-07036. Dr Litonjua is supported by National Heart, Lung, and Blood Institute grant KO8 HL-03870 and a research grant from the American Lung Association.

☆☆ Reprint requests: Augusto A. Litonjua, Channing Laboratory, 181 Longwood Ave, Boston, MA 02115.

PII: S0091-6749(02)01422-7

doi: 10.1067/mai.2002.128948

The Journal of Allergy and Clinical Immunology
Volume 110, Issue 5 , Pages 736-742 , November 2002

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