The Journal of Allergy and Clinical Immunology
Volume 108, Issue 2 , Pages 310-312 , August 2001

T-cell apoptosis in ICF syndrome

  • Annalisa Pezzolo, PhD

      Affiliations

    • Laboratory of Oncology, G. Gaslini Institute Largo G. Gaslini 5 16148 Genova Italy
    • ,
  • Ignazia Prigione, PhD

      Affiliations

    • Laboratory of Oncology, G. Gaslini Institute Largo G. Gaslini 5 16148 Genova Italy
    • ,
  • Paola Facchetti, PhD

      Affiliations

    • Laboratory of Oncology, G. Gaslini Institute Largo G. Gaslini 5 16148 Genova Italy
    • ,
  • Emanuela Castellano, MD

      Affiliations

    • Laboratories of Cytogenetics and 3rd Division of Pediatrics, G. Gaslini Institute, Genova
    • ,
  • Maurizio Viale, PhD

      Affiliations

    • Laboratory of Pharmacology, National Institute for Cancer Research, Genova
    • ,
  • Giorgio Gimelli, PhD

      Affiliations

    • Laboratories of Cytogenetics and 3rd Division of Pediatrics, G. Gaslini Institute, Genova
    • ,
  • Vito Pistoia, MD

      Affiliations

    • Laboratory of Oncology, G. Gaslini Institute Largo G. Gaslini 5 16148 Genova Italy

References 

  1. Tiepolo L, Maraschio P, Gimelli G, Cuoco C, Gargani GF, Romano C. Multibranched chromosomes 1, 9 and 16 in a patient with combined IgA and IgE deficiency. Hum Genet. 1979;51:127–137
  2. Smeets DFCM, Moog U, Weemaes CMR, Vaes-Peeters G, Merkx GFM, Niehof JP, et al.  ICF syndrome: a new case and review of the literature. Hum Genet. 1994;94:240–246
  3. Franceschini P, Martino S, Ciocchini M, Ciuti E, Vardeu MP, Guala A, et al.  Variability of clinical and immunological phenotype in immunodeficiency-centromeric instability-facial anomalies syndrome: report of two new patients and review of the literature. Eur J Pediatr. 1995;154:840–846
  4. Gimelli G, Varone P, Pezzolo A, Lerone M, Pistoia V. ICF syndrome with variable expression in sibs. J Med Genet. 1993;30:429–432
  5. Hansen RS, Wijmenga C, Ping L, Stanek AM, Canfield TK, Weemaes C, et al.  The DNMT3B DNA methyltransferase gene is mutated in the ICF immunodeficiency syndrome. Proc Natl Acad Sci U S A. 1999;96:14412–14417
  6. Xu GL, Bestor TH, Bourc’his D, Hsieh C, Tommerup N, Bugge M, et al.  Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature. 1999;402:187–191
  7. Wijmenga C, Hansen RS, Gimelli G, Bjorck EJ, Davies EG, Valentine D, et al.  Genetic variation in ICF syndrome: evidence for genetic heterogeneity. Hum Mutat. 2000;16:509–517

PII: S0091-6749(01)70086-3

doi: 10.1067/mai.2001.116863

The Journal of Allergy and Clinical Immunology
Volume 108, Issue 2 , Pages 310-312 , August 2001

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