The Journal of Allergy and Clinical Immunology
Volume 116, Issue 1 , Pages 223-225 , July 2005

Childhood cat exposure–related tolerance is associated with IL1A and IL10 polymorphisms

  • Jussi Karjalainen, MD, PhD

      Affiliations

    • Tampere University Hospital, Department of Respiratory Medicine
    • ,
  • Miia Virta, MD

      Affiliations

    • Department of Microbiology and Immunology, University of Tampere Medical School
    • ,
  • Tanja Pessi, PhD

      Affiliations

    • Department of Microbiology and Immunology, University of Tampere Medical School
    • ,
  • Janne Hulkkonen, MD, PhD

      Affiliations

    • Department of Microbiology and Immunology, University of Tampere Medical School
    • ,
  • Markku M. Nieminen, MD, PhD

      Affiliations

    • Tampere University Hospital, Department of Respiratory Medicine
    • ,
  • Mikko Hurme, MD, PhD

      Affiliations

    • Department of Microbiology and Immunology, University of Tampere Medical School
    • Tampere University Hospital, Centre for Laboratory Medicine, FIN-33014 Tampere, Finland

References 

  1. Roost HP, Kunzli N, Schindler C, Jarvis D, Chinn S, Perruchoud AP, et al. Role of current and childhood exposure to cat and atopic sensitization. J Allergy Clin Immunol. 1999;104:941–947
  2. Ownby DR, Johnson CC, Peterson EL. Exposure to dogs and cats in the first year of life and risk of allergic sensitization at 6 to 7 years of age. JAMA. 2002;288:963–972
  3. Gern JE, Reardon CL, Hoffjan S, Nicolae D, Li ZH, Roberg KA, et al. Effects of dog ownership and genotype on immune development and atopy in infancy. J Allergy Clin Immunol. 2004;113:307–314
  4. Platts-Mills TA. Paradoxical effect of domestic animals on asthma and allergic sensitization. JAMA. 2002;288:1012–1014
  5. Karjalainen J, Hulkkonen J, Pessi T, Huhtala H, Nieminen MM, Aromaa A, et al. The IL1A genotype associates with atopy in nonasthmatic adults. J Allergy Clin Immunol. 2002;110:429–434
  6. Karjalainen J, Hulkkonen J, Nieminen MM, Huhtala H, Aromaa A, Klaukka T, et al. IL-10 gene promoter region polymorphism is associated with eosinophil count and circulating IgE in adult asthma. Clin Exp Allergy. 2003;33:78–83
  7. Hulkkonen J, Pertovaara M, Antonen J, Lahdenpohja N, Pasternack A, Hurme M. Genetic association between interleukin-10 promoter region polymorphisms and primary Sjogren's syndrome. Arthritis Rheum. 2001;44:176–179
  8. Perzanowski MS, Ronmark E, Platts-Mills TAE, Lundback B. Effect of cat and dog ownership on sensitization and development of asthma among preteenage children. Am J Respir Crit Care Med. 2002;166:696–702

 Supported by the Academy of Finland, the Rehabilitation Funds of the Finnish Social Insurance Institution, the Medical Research Fund of Tampere University Hospital, and the Tampere Tuberculosis Foundation.

PII: S0091-6749(05)00603-2

doi: 10.1016/j.jaci.2005.03.026

The Journal of Allergy and Clinical Immunology
Volume 116, Issue 1 , Pages 223-225 , July 2005

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