Perception of risk associated with asthma research procedures among adolescents, parents, and pediatricians

Study I: Mean risk ratings associated with asthma research procedures. Repeated-measures MANOVA: Adolescents: F (9, 27)=14.56, P < .001 Parents: F (9, 27)=53.69, P<.001 Pediatricians: F (9, 32)=52.88, P < .001 P values for pairwise comparisons of risk of venipuncture with research procedures by group (adolescents, parents, and pediatricians). A, Adolescent: rating is significantly different from venipuncture (P < .005); B, Parent: rating is significantly different from venipuncture (P < .005); C, Pediatrician: rating is significantly different from venipuncture (P < .005).

Study II: Mean benefit ratings associated with asthma research procedures. P values for 1-way ANOVA for each benefit rating among groups (adolescents, parents, and pediatricians). A, P < .001. Multiple comparisons for each asthma research procedure with the Tukey HSD test for post-hoc comparisons: B, Venipuncture: Parents>adolescents-pediatricians Parents>adolescents, P < .05 Parents>pediatricians, P < .001 C, Spirometry: Parents>adolescents-pediatricians Parents>adolescents, P < .001 Parents>pediatricians, P < .001 D, Exhaled nitric oxide (NO): Parents>adolescents-pediatricians Parents>adolescents, P < .01 Parents>pediatricians, P < .01 E, Placebo: Adolescents-parents>pediatricians Adolescents>pediatricians, P<.001 Parents>pediatricians, P < .01 F, Psychological tests: Parents>adolescents Parents>adolescents, P < .01 Parents=pediatricians and adolescents=pediatricians.