The Journal of Allergy and Clinical Immunology
Volume 114, Issue 5 , Pages 1189-1194 , November 2004

Immune responses to mosquito saliva in 14 individuals with acute systemic allergic reactions to mosquito bites

  • Zhikang Peng, MD

      Affiliations

    • From the Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg
    • Corresponding Author InformationReprint requests: Zhikang Peng, MD, Department of Pediatrics and Child Health, University of Manitoba, 532-715 McDermot Ave, Winnipeg, Manitoba, Canada, R3E 3P4.
  • ,
  • Andrew N. Beckett, BSc

      Affiliations

    • From the Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg
  • ,
  • Renata J. Engler, MD

      Affiliations

    • Walter Reed Army Medical Center, Washington
  • ,
  • Donald R. Hoffman, PhD

      Affiliations

    • Department of Pathology and Laboratory Medicine, East Carolina University, Greenville
  • ,
  • Nancy L. Ott, MD

      Affiliations

    • Southdale Pediatric Associates, Ld, Edina
  • ,
  • F. Estelle R. Simons, MD, FRCPC

      Affiliations

    • From the Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, University of Manitoba, Winnipeg

Received 3 June 2004 ,Revised 5 August 2004 ,Accepted 6 August 2004.

References 

  1. Simons FER, Peng Z. Mosquito allergy. In:  Levine MI,  Lockey RF editor. Milwaukee (WI): American Academy of Allergy, Asthma and Immunology monograph on insect allergy; 2003;p. 175–203
  2. Benaim-Pinto C, Fassrainer A. Intradermal immunotherapy in children with severe skin inflammatory reactions to Aedes aegypti and Culex quinquefasciatus mosquito bites. [letter] Int J Dermatol. 1990;29:600–601
  3. Simons FER, Peng Z. Skeeter syndrome. J Allergy Clin Immunol. 1999;104:705–707
  4. Engler RJ. Mosquito bite pathogenesis in necrotic skin reactors. Curr Opin Allergy Clin Immunol. 2001;1:349–352
  5. Gluck JC, Pacin MP. Asthma from mosquito bites: a case report. Ann Allergy. 1986;56:492–493
  6. Garcia Ortiz JC, Cosmes Martin P. [Anaphylaxis from a mosquito bite]. Med Clin (Barc). 1994;102:157
  7. McCormack DR, Salata KF, Hershey JN, Carpenter GB, Engler RJ. Mosquito bite anaphylaxis: immunotherapy with whole body extracts. Ann Allergy Asthma Immunol. 1995;74:39–44
  8. Galindo PA, Gomez E, Borja J, Feo F, Garcia R, Lombardero M, et al. Mosquito bite hypersensitivity. Allergol Immunopathol (Madr). 1998;26:251–254
  9. Hassoun S, Drouet M, Sabbah A. [Anaphylaxis caused by a mosquito: 2 case reports]. Allerg Immunol (Paris). 1999;31:285–287
  10. Gluck J, Rogala B. [Mosquito bites hypersensitivity: clinical and therapeutic approach]. Wiad Lek. 2000;53:175–179
  11. Valenzuela JG, Pham VM, Garfield MK, Francischetti IM, Ribeiro JM. Toward a description of the sialome of the adult female mosquito Aedes aegypti. Insect Biochem Mol Biol. 2002;32:1101–1122
  12. Racioppi JV, Spielman A. Secretory proteins from the salivary glands of adult Aedes aegypti mosquitoes. Insect Biochem. 1987;17:503–511
  13. Peng Z, Li H, Simons FER. Immunoblot analysis of salivary allergens in 10 mosquito species with worldwide distribution and the human IgE responses to these allergens. [published erratum appears in J Allergy Clin Immunol 1998;101(6 Pt 1):746] J Allergy Clin Immunol. 1998;101:498–505
  14. Peng Z, Simons FER. Mosquito allergy: immune mechanisms and recombinant salivary allergens. Int Arch Allergy Immunol. 2004;113:198–209
  15. Mellanby K. Man's reaction to mosquito bites. Nature. 1946;158:554
  16. Peng Z, Simons FER. A prospective study of naturally acquired sensitization and subsequent desensitization to mosquito bites and concurrent antibody responses. J Allergy Clin Immunol. 1998;101:284–286
  17. Reunala T, Brummer-Korvenkontio H, Rasanen L, Francois G, Palosuo T. Passive transfer of cutaneous mosquito-bite hypersensitivity by IgE anti-saliva antibodies. J Allergy Clin Immunol. 1994;94:902–906
  18. Peng Z, Yang M, Simons FER. Measurement of mosquito Aedes vexans salivary gland-specific IgE and IgG antibodies and the distribution of these antibodies in human sera. Ann Allergy Asthma Immunol. 1995;74:259–264
  19. Oka K. Correlation of Aedes albopictus bite reaction with IgE antibody assay and lymphocyte transformation test to mosquito salivary antigens. J Dermatol. 1989;16:341–347
  20. Suzuki S, Negishi K, Tomizawa S, Shibasaki M, Kuroume T. A case of mosquito allergy. Immunological studies. Acta Allergol. 1976;31:428–441
  21. Peng Z, Li H, Simons FER. Immunoblot analysis of salivary allergens in 10 mosquito species with worldwide distributions and the IgE responses to these allergens. J Allergy Clin Immunol. 1998;101:498–505
  22. Shen HD, Chen CC, Chang HN, Chang LY, Tu WC, Han SH. Human IgE and IgG antibodies to mosquito proteins detected by the immunoblot technique. Ann Allergy. 1989;63:143–146
  23. Peng Z, Yang M, Simons FER. Immunologic mechanisms in mosquito allergy: correlation of skin reactions with specific IgE and IgG antibodies and lymphocyte proliferation response to mosquito antigens. Ann Allergy Asthma Immunol. 1996;77:238–244
  24. Peng Z, Simons FER. Comparison of proteins, IgE, and IgG binding antigens, and skin reactivity in commercial and laboratory-made mosquito extracts. Ann Allergy Asthma Immunol. 1996;77:371–376
  25. Panzani RC, Ariano R. Arthropods and invertebrates allergy (with the exclusion of mites): the concept of panallergy. Allergy. 2001;56(suppl 69):1–22
  26. Baldo BA, Panzani RC. Detection of IgE antibodies to a wide range of insect species in subjects with suspected inhalant allergies to insects. Int Arch Allergy Appl Immunol. 1988;85:278–287
  27. Eriksson NE, Ryden B, Jonsson P. Hypersensitivity to larvae of chironomids (non-biting midges). Cross-sensitization with crustaceans. Allergy. 1989;44:305–313
  28. Galindo PA, Lombardero M, Mur P, Feo F, Gomez E, Borja J, et al. Patterns of immunoglobulin E sensitization to chironomids in exposed and unexposed subjects. J Investig Allergol Clin Immunol. 1999;9:117–122
  29. Sabbah A, Hassoun S, Drouet M, Lauret MG, Doucet M. [The wasp/mosquito syndrome]. Allerg Immunol (Paris). 1999;31:175–184
  30. Peng Z, Li H, Simons FER. Immunoblot analysis of IgE and IgG binding antigens in extracts of mosquitos Aedes vexans, Culex tarsalis and Culiseta inornata. Int Arch Allergy Immunol. 1996;110:46–51
  31. Peng Z, Simons FE. Cross-reactivity of skin and serum specific IgE responses and allergen analysis for three mosquito species with worldwide distribution. J Allergy Clin Immunol. 1997;100:192–198
  32. Peng Z, Beckett AN, Wang Q, Simons FER. A comparison of the UniCap test with an ELISA in the diagnosis of individuals with systemic or severe local reactions to mosquito bites. J Allergy Clin Immunol. 2003;111(suppl):S207
  33. Peng Z, Lam H, Xu W, Cheng L, Chen YL, Simons FER. Characterization and clinical relevance of two recombinant mosquito Aedes aegypti salivary allergens, rAed a 1 and rAed a 2. J Allergy Clin Immunol. 1998;101(suppl):S32
  34. Simons FER, Peng Z. Mosquito allergy: recombinant mosquito salivary allergens for new diagnostic tests. Int Arch Allergy Immunol. 2001;124:403–405
  35. Xu W, Peng Z, Simons FER. Isolation of a cDNA encoding a 30 kDa IgE-binding protein of mosquito Aedes aegypti saliva. J Allergy Clin Immunol. 1998;101(suppl):S203
  36. Peng Z, Xu W, James AA, Lam H, Sun D, Cheng L, et al. Expression, purification, characterization, and clinical relevance of rAed a 1—a 68 kDa recombinant mosquito Aedes aegypti salivary allergen. Int Immunol. 2001;13:1445–1452
  37. Li C, Beckett AN, James AA, Simons FER, Arthur G, Peng Z. Diagnosis of mosquito allergy: role of a new 67 kDa recombinant Aedes aegypti salivary allergen rAed a 4. Allergy Clin Immunol Int: J World Allergy Org. 2003;(suppl 1):195
  38. Beckett AN, Sun W, Simons FER, Ma Y, Peng Z. Role of recombinant mosquito salivary allergens in the diagnosis of individuals with allergic reactions to mosquito bites. J Allergy Clin Immunol. 2004;113(suppl):S74

 Supported by the Children's Hospital Foundation of Manitoba, Inc, and the Paul H. T. Thorlakson Research Fund for Andrew Beckett's BSc medicine studentship.

PII: S0091-6749(04)02218-3

doi: 10.1016/j.jaci.2004.08.014

The Journal of Allergy and Clinical Immunology
Volume 114, Issue 5 , Pages 1189-1194 , November 2004