The Journal of Allergy and Clinical Immunology
Volume 112, Issue 2 , Pages 438-444 , August 2003

The −159 C→T polymorphism of CD14 is associated with nonatopic asthma and food allergy

  • Jessica G. Woo, MHSA

      Affiliations

    • the Division of Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati Medical Center Cincinnati, Ohio
    • ,
  • Amal Assa’ad, MD

      Affiliations

    • the Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center Cincinnati, Ohio
    • ,
  • Angela B. Heizer, BA

      Affiliations

    • the Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center Cincinnati, Ohio
    • ,
  • Jonathan A. Bernstein, MD

      Affiliations

    • the Division of Immunology, Department of Internal Medicine, University of Cincinnati Medical Center. Cincinnati, Ohio
    • ,
  • Gurjit K. Khurana Hershey, MD, PhD

      Affiliations

    • the Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center Cincinnati, Ohio

Received 8 January 2003 ,Revised 1 May 2003 ,Accepted 2 May 2003.

References 

  1. Expert Panel Report 2 . Guidelines for the diagnosis and management of asthma. Bethesda, Md: National Institutes of Health, National Heart, Lung, and Blood Institute; 1997; NIH publication no. 97-4051
  2. Sampson HA. Food allergy. Part 1: immunopathogenesis and clinical disorders. J Allergy Clin Immunol. 1999;103:717–728
  3. Sampson HA. Food allergy. Part 2: diagnosis and management. J Allergy Clin Immunol. 1999;103:981–989
  4. Neddenriep D, Schumacher JJ, Lemen RJ. Asthma in childhood. Curr Probl Pediatr. 1989;19:325–388
  5. Harris JR, Magnus P, Samuelson SO, Tambs K. No evidence for effects of family environment on asthma. A retrospective study of Norwegian twins. Am J Respir Crit Care Med. 1997;156:43–49
  6. Laitinen T, Rasanen M, Kaprio J, Koskenvuo M, Laitinen L. Importance of genetic factors in asthma: a population based twin-family study. Am J Respir Crit Care Med. 1998;157:1073–1078
  7. Ober C, Tsalenko A, Parry R, Cox NJ. A second-generation genomewide screen for asthma-susceptibility alleles in a founder population. Am J Hum Genet. 2000;67:1154–1162
  8. Meyers DA, Postma DS, Panhuysen CI, et al.  Evidence for a locus regulating total serum IgE levels mapping to chromosome 5. Genomics. 1994;23:464–470
  9. Marsh DG, Neely JD, Breazeale DR, et al.  Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science. 1994;264:1152–1156
  10. Haagerup A, Bjerke T, Schiotz PO, Binderup HG, Dahl R, Kruse TA. Asthma and atopy—a total genome scan for susceptibility genes. Allergy. 2002;57:680–686
  11. Postma DS, Bleecker ER, Amelung PJ, et al.  Genetic susceptibility to asthma—bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med. 1995;333:894–900
  12. Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2:675–680
  13. Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FD. A polymorphism in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol. 1999;20:976–983
  14. Koppelman GH, Reijmerink NE, Colin Stine O, et al.  Association of a promoter polymorphism of the CD14 gene and atopy. Am J Respir Crit Care Med. 2001;163:965–969
  15. Karhukorpi J, Yan Y, Niemela S, et al.  Effect of CD14 promoter polymorphism and H. pylori infection and its clinical outcomes on circulating CD14. Clin Exp Immunol. 2002;128:326–332
  16. Lapa e Silva JR, Possebon da Silva MD, Lefort J, Vargaftig BB. Endotoxins, asthma, and allergic immune responses. Toxicology. 2000;152:31–35
  17. Gao PS, Mao XQ, Baldini M, et al.  Serum total IgE levels and CD14 on chromosome 5q31. Clin Genet. 1999;56:164–165
  18. Kusunoki T, Nakahata T, Miyanomae T, Inoue Y. Possible dual effect of CD14 molecule on atopy. Am J Respir Crit Care Med. 2002;165:551–552
  19. American Thoracic Society . Lung function testing: selection of reference values and interpretive strategies. Am Rev Respir Dis. 1991;144:1202–1218
  20. American Thoracic Society . Standardization of spirometry: 1994 update. Am J Respir Crit Care Med. 1994;152:1107–1136
  21. Bernstein IL, Storms WW. Practice parameters for allergy diagnostic testing. Ann Allergy Asthma Immunol. 1995;75(suppl):553–625
  22. 2000 Census figures for Cincinnati Metropolitan Statistical Area. Available at www.censusscope.orgFebruary 11, 2003; Accessed
  23. Marsh DG, Hsu SH, Roebber M. HLA-Dw2: a genetic marker for human immune response to short ragweed pollen allergen Ra5. I. Response resulting primarily from antigenic exposure. J Exp Med. 1982;155:1439–1451
  24. Young RP, Dekker JW, Wordsworth BP, et al.  HLA-DR and HLA-DP genotypes and immunoglobulin E responses to common major allergens. Clin Exp Allergy. 1994;24:431–439
  25. Shirakawa T, Li A, Dubowitz M, et al.  Association between atopy and variants of the β subunit of the high affinity immunoglobulin E receptor. Nat Genet. 1994;7:125–130
  26. Graves PE, Kabesch M, Halonen M, et al.  A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol. 2000;105:506–513
  27. van der Pouw Kraan TCTM, van Veen A, Boeije LCM, et al.  An IL-13 promotor polymorphism associated with increased risk of allergic asthma. Gene Immunol. 1999;1:61–65
  28. Nicolaides NC, Holroyd KJ, Ewart SL, et al.  Interleukin 9: a candidate gene for asthma. Proc Natl Acad Sci U S A. 1997;94:13175–13180
  29. Braun-Fahrlander C, Riedler J, Herz U, et al.  Environmental exposure to endotoxin and its relation to asthma in school-age children. N Engl J Med. 2002;347:869–877
  30. Arbour NC, Lorenz E, Schutte BC, et al.  TLR4 mutations are associated with endotoxin hyporesponsiveness in humans. Nat Genet. 2000;25:187–191
  31. Reis e Sousa C, Sher A, Kaye P. The role of dendritic cells in the induction and regulation of immunity to microbial infection. Curr Opin Immunol. 1999;11:392–399
  32. Baldini M, Vercelli D, Martinez FD. CD14: an example of gene by environment interaction in allergic disease. Allergy. 2002;57:188–192
  33. Vercelli D. The functional genomics of CD14 and its role in IgE responses: an integrated view. J Allergy Clin Immunol. 2002;109:14–21
  34. Kusunoki T, Wright SD, Inoue Y, Yoshida Y, Yondeda K. Serum levels of soluble CD14 in allergic inflammation. Allergol Int. 1998;47:271–278
  35. LeVan TD, Bloom JW, Bailey TJ, et al.  A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol. 2001;167:5838–5844
  36. Sampath D, Castro M, Look DC, Holtzman MJ. Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma. J Clin Invest. 1999;103:1353–1361
  37. Sicherer SH, Furlong TJ, Maes HH, Desnick RJ, Sampson HA, Gelb BD. Genetics of peanut allergy: a twin study. J Allergy Clin Immunol. 2000;106:53–56
  38. Gawronska-Szklarz B, Pawlik A, Czaja-Bulsa G, Gornik W, Luszawska-Kutrzeba T, Wrzesniewska J. Genotype of N-acetyltransferase 2 (NAT2) polymorphism in children with immunoglobulin E-mediated food allergy. Clin Pharmacol Ther. 2001;69:372–378

☆ Supported by NIH R01AI46652-01A1 (Dr Hershey). Dr Woo was supported by a National Institute of Environmental Health Sciences' Molecular Epidemiology in Children's Environmental Health Training Grant, T32-ES 10957.

☆☆ Reprint requests: Gurjit K. Khurana Hershey, MD, PhD, Division of Allergy and Immunology, Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH 45229.

PII: S0091-6749(03)01601-4

doi: 10.1067/mai.2003.1634

The Journal of Allergy and Clinical Immunology
Volume 112, Issue 2 , Pages 438-444 , August 2003

Article Tools

* Image Usage & Resolution