The Journal of Allergy and Clinical Immunology
Volume 111, Issue 2 , Pages 402-407 , February 2003

Current mite, cat, and dog allergen exposure, pet ownership, and sensitization to inhalant allergens in adults

Received 7 June 2002 ,Revised 6 September 2002 ,Accepted 8 October 2002.

References 

  1. Lau S, Falkenhorst G, Weber A, Werthmann I, Lind P, Buettner-Goetz P, et al.  High mite-allergen exposure increases the risk of sensitization in atopic children and young adults. J Allergy Clin Immunol. 1989;84:718–725
  2. Huss K, Adkinson NF, Eggleston PA, Dawson C, Van Natta ML, Hamilton RG. House dust mite and cockroach exposure are strong risk factors for positive allergy skin test responses in the Childhood Asthma Management Program. J Allergy Clin Immunol. 2001;107:48–54
  3. Eggleston PA, Rosenstreich D, Lynn H, Gergen P, Baker D, Kattan M, et al.  Relationship of indoor allergen exposure to skin test sensitivity in inner-city children with asthma. J Allergy Clin Immunol. 1998;102:563–570
  4. Phipatanakul W, Eggleston PA, Wright EC, Wood RA. Mouse allergen. I. The prevalence of mouse allergen in inner-city homes: the National Cooperative Inner-City Asthma Study. J Allergy Clin Immunol. 2000;106:1070–1074
  5. Phipatanakul W, Eggleston PA, Wright EC, Wood RA. Mouse allergen, II: the relationship of mouse allergen exposure to mouse sensitization and asthma morbidity in inner-city children with asthma. J Allergy Clin Immunol. 2000;106:1075–1080
  6. Lindfors A, van Hage-Hamsten M, Rietz H, Wickman M, Nordval SL. Influence of interaction of environmental risk factors and sensitisation in young asthmatic children. J Allergy Clin Immunol. 1999;104:755–762
  7. Wahn U, Lau S, Bergmann R, Kulig M, Forster J, Bergmann K, et al.  Indoor allergen exposure is a risk factor for sensitisation during the first 3 years of life. J Allergy Clin Immunol. 1997;99:763–769
  8. Lau S, Illi S, Sommerfeld C, Niggemann B, Bergmann R, von Mutius E, et al.  Early exposure to house dust mite and cat allergens and development of childhood asthma: a cohort study. Lancet. 2000;356:1392–1397
  9. Roost HP, Kunzli N, Schindler C, Jarvis D, Chinn S, Perruchoud AP, et al.  Role of current and childhood exposure to cat and atopic sensitization: European Community Respiratory Health Survey. J Allergy Clin Immunol. 1999;104:941–947
  10. Sporik R, Squillace SP, Ingram JM, Rakes G, Honsinger RW, Platts Mills TAE. Mite, cat and cockroach exposure, allergen sensitisation and asthma in children: a case-control study of 3 schools. Thorax. 1999;54:675–680
  11. Hesselmar B, Aberg N, Aberg B, Eriksson B, Bjorksten B. Does early exposure to cat or dog protect against later allergy development?. Clin Exp Allergy. 1999;29:611–617
  12. Custovic A, Simpson BM, Simpson A, Hallam C, Craven M, Brutsche M, et al.  Manchester Asthma And Allergy Study: low allergen environment can be achieved and maintained during pregnancy and in early life. J Allergy Clin Immunol. 2000;105:252–258
  13. Simpson BM, Custovic A, Simpson A, Hallam CL, Walsh D, Marolia H, et al.  Manchester Asthma and Allergy Study (NacMAAS): Risk Factors for Asthma and Allergic Disorders In Adults. Clin Exp Allergy. 2001;31:391–399
  14. Custovic A, Simpson BM, Simpson A, Kissen P, Woodcock A. Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during the first year of life: a randomised trial. Lancet. 2001;358:188–193
  15. Luczynska CM, Arruda LK, Platts-Mills TAE, Miller JD, Lopez M, Chapman MD. A two site monoclonal antibody ELISA for the quantification of the major Dermatophagoides spp. allergens, Der p I and Der f I. J Immunol Methods. 1989;118:227–235
  16. Custovic A, Smith A, Pahdi H, Green RM, Chapman MD, Woodcock A. Distribution, aerodynamic characteristics and removal of the major cat allergen Fel d 1 in British homes. Thorax. 1998;53:33–38
  17. Custovic A, Green R, Fletcher A, Smith A, Pickering CAC, Chapman MD, et al.  Aerodynamic properties of the major dog allergen, Can f 1: distribution in homes, concentration and particle size of allergen in the air. Am J Respir Crit Care Med. 1997;155:94–98
  18. Anyo G, Brunekreef B, de Mear G, Arts F, Janssen N, van Liet P. Early current and past pet ownership. Clin Exp Allergy. 2002;32:361–366
  19. Braun-Fahrlander C, Gassner M, Grize L, Neu U, Sennhauser FH, Varonier HS, et al.  Prevalence of hay fever and allergic sensitisation in farmers' children and their peers living in the same rural community. Clin Exp Allergy. 1999;29:28–34
  20. Platts-Mills TAE, Vaughan J, Squillace S, Woodfolk J, Sporik R. Decreased risk of sensitisation and asthma in children with high exposure to cat allergen is associated with a modified Th2 response. Lancet. 2001;357:752–756
  21. Platts-Mills TAE, Perzanowski M, Woodfolk JA, Lundback B. Relevance of early or current pet ownership on the prevalence of allergic disease. Clin Exp Allergy. 2002;32:335–338
  22. Remes ST, Castro-Rodriguez JA, Holberg CJ, Martinez FD, Wright AL. Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopy. J Allergy Clin Immunol. 2001;108:509–515
  23. Custovic A, Hallam CL, Simpson BM, Craven M, Simpson A, Woodcock A. Decreased prevalence of sensitization to cats with high exposure to cat allergen. J Allergy Clin Immunol. 2001;108:537–539
  24. Gore RB, Hadi EA, Craven M, Smillie FS, O'Meara TJ, Tovey ER, et al.  Personal exposure to house dust mite allergen in bed: nasal air sampling and reservoir allergen levels. Clin Exp Allergy. 2002;32:856–859
  25. Robinson C, Baker SF, Garrod DR. Peptidase allergens, occludins and claudins: do their interactions facilitate the development of hypersensitivity reactions at mucosal surfaces?. Clin Exp Allergy. 2001;31:186–192
  26. Wan H, Winton HL, Soeller C, Tovey ER, Gruenert DC, Thompson PJ, et al.  Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J Clin Invest. 1999;104:123–133
  27. Schulz O, Sewell HF, Shakib F. The interaction between the dust mite antigen Der p 1 and cell-signalling molecules in amplifying allergic disease. Clin Exp Allergy. 1999;29:439–444

 Supported by The National Asthma Campaign.

☆☆ Reprint requests: Adnan Custovic, MD, PhD, North West Lung Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, United Kingdom.

PII: S0091-6749(02)91317-5

doi: 10.1067/mai.2003.55

The Journal of Allergy and Clinical Immunology
Volume 111, Issue 2 , Pages 402-407 , February 2003