The Journal of Allergy and Clinical Immunology
Volume 111, Issue 1 , Pages 38-44 , January 2003

Unraveling the mission of FcϵRI on antigen-presenting cells

Received 7 July 2002 ,Revised 3 September 2002 ,Accepted 16 September 2002.

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    Structural characteristics of IgE and the IgE-binding receptors. The structure of the IgE molecule with the constant region (Fc) and the structural characteristics and cellular distributions of the te

    Structural characteristics of IgE and the IgE-binding receptors. The structure of the IgE molecule with the constant region (Fc) and the structural characteristics and cellular distributions of the tetrameric and trimeric variants of FcϵRI, FcϵRII, and the soluble form (sFc ϵRII) are summarized.

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    Functional characteristics of FcϵRI on effector cells and APCs of atopic and nonatopic donors. The classical tetrameric FcϵRI expressed on effector cells of both a topic and nonatopic donors is shown

    Functional characteristics of FcϵRI on effector cells and APCs of atopic and nonatopic donors. The classical tetrameric FcϵRI expressed on effector cells of both a topic and nonatopic donors is shown at the top . In contrast, the trimeric variant of FcϵRI is distinctly expressed on APCs of atopic and nonatopic individuals, as shown at the bottom .

☆ Reprint requests: Natalija Novak, MD, Department of Dermatology, Friedrich-Wilhelms-University, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany.

PII: S0091-6749(02)91264-9

doi: 10.1067/mai.2003.2

The Journal of Allergy and Clinical Immunology
Volume 111, Issue 1 , Pages 38-44 , January 2003

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