The Journal of Allergy and Clinical Immunology
Volume 106, Issue 1 , Pages 159-166 , July 2000

Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/Nga mice

  • Mayumi Kotani, BSc

      Affiliations

    • Research and Development Center, Sunstar Incorporation, Osaka Osaka, Japan
    • ,
  • Motonobu Matsumoto, BSc

      Affiliations

    • Research and Development Center, Sunstar Incorporation, Osaka Osaka, Japan
    • ,
  • Akihito Fujita, BSc

      Affiliations

    • Research and Development Center, Sunstar Incorporation, Osaka Osaka, Japan
    • ,
  • Shinji Higa, MD

      Affiliations

    • Department III of Internal Medicine, Osaka University Medical School, Osaka. Osaka, Japan
    • ,
  • Way Wang, MD, PhD

      Affiliations

    • Department III of Internal Medicine, Osaka University Medical School, Osaka. Osaka, Japan
    • ,
  • Masaki Suemura, MD, PhD

      Affiliations

    • Department III of Internal Medicine, Osaka University Medical School, Osaka. Osaka, Japan
    • ,
  • Tadamitsu Kishimoto, MD, PhD

      Affiliations

    • Department III of Internal Medicine, Osaka University Medical School, Osaka. Osaka, Japan
    • ,
  • Toshio Tanaka, MD, PhD

      Affiliations

    • Department III of Internal Medicine, Osaka University Medical School, Osaka. Osaka, Japan

Received 11 February 2000 ,Revised 16 March 2000 ,Accepted 16 March 2000.

References 

  1. Williams H, Robertson C, Stewart A, Ait-Khaled N, Anabwani G, Anderson R, et al.  Worldwide variations in the prevalence of symptoms of atopic eczema in the international study of asthma and allergies in childhood. J Allergy Clin Immunol. 1999;103:125–138
  2. Cooper KD. Atopic dermatitis: recent trends in pathogenesis and therapy. J Invest Dermatol. 1994;102:128–137
  3. Grewe M, Bruijnzeel-Koomen CA, Schopf E, Thepen T, Langeveld-Wildschut AG, Ruzicka T, et al.  A role for Th1 and Th2 cells in immunopathogenesis of atopic dermatitis. Immunol Today. 1998;19:359–361
  4. Leung DYM. Atopic dermatitis: immunobiology and treatment with immune modulators. Clin Exp Immunol. 1997;107:25–30
  5. Graham-Brown RA. Therapeutics in atopic dermatitis. Adv Dermatol. 1997;13:3–31
  6. Fewtrell CMS, Gomperts BD. Effect of flavone inhibitors of transport ATPases on histamine secretion from rat mast cells. Nature. 1977;265:635–636
  7. Chakravarty N. The role of plasma membrane Ca++-Mg++ activated adenosine triphosphatase of rat mast cells on histamine release. Acta Pharmacol Toxicol. 1980;47:223–235
  8. Amellal M, Bronner C, Briancon F, Haag M, Anton R, Landry Y. Inhibition of mast cell histamine release by flavonoids and biflavonoids. Planta Med. 1985;1:16–20
  9. Cheong H, Ryu SY, Oak MH, Cheon SH, Yoo GS, Kim KM. Studies of structure activity relationship of flavonoids for the anti-allergic actions. Arch Pharm Res. 1998;21:478–480
  10. Pagonis C, Tauber AL, Pavlotsky N, Simons ER. Flavonoid impairment of neutrophil response. Biochem Pharmacol. 1986;35:237–245
  11. Funayama S, Hikino H. Hypotensive principle of Diospyros khaki leaves. Chem Pharm Bull. 1979;27:2865–2868
  12. Kameda K, Takaku T, Okuda H, Kimura Y, Okuda T, Hatano T, et al.  Inhibitory effects of various flavonoids isolated from leaves of persimmon on angiotensin-converting enzyme activity. J Nat Prod. 1987;50:680–683
  13. Ishiguro K, Oku H. Antipruritic effect of flavonol and 1,4-naphthoquinone derivatives from Impatiens balsamina L. Phytother Res. 1997;11:343–347
  14. Kotani M, Fujita A, Tanaka T. Inhibitory effects of persimmon leaf extract on allergic reaction in human basophilic leukemia cells and mice. J Jpn Soc Nutr Food Sci. 1999;52:147–151
  15. Gounni AS, Lamkhioued B, Ochiai K, Tanaka Y, Delaporte E, Capron A, et al.  High-affinity IgE receptor on eosinophils is involved in defense against parasites. Nature. 1994;367:183–186
  16. Kishi K. A new leukemia cell line with Philadelphia chromosome characterized as basophil precursors. Leuk Res. 1985;9:381–390
  17. Inagaki N, Goto S, Nagai H, Koda A. Mouse ear PCA as a model for evaluating antianaphylactic agents. Int Arch Allergy Appl Immunol. 1984;74:91–92
  18. Matsuda H, Watanabe N, Geba GP, Sperl J, Tsudzuki M, Hiroi J, et al.  Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. Int Immunol. 1997;9:461–466
  19. Matsumoto M, Ra C, Kawamoto K, Sato H, Itakura A, Sawada J, et al.  IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis. J Immunol. 1999;162:1056–1063
  20. Middleton E, Kandaswami C. Effects of flavonoids on immune and inflammatory cell functions. Biochem Parmacol. 1992;43:1167–1179
  21. Kakegawa H, Matsumoto H, Endo K, Satoh T, Nonaka G, Nishioka I, et al.  Inhibitory effects of tannins on hyaluronidase activation and on the degranulation from rat mensentery mast cells. Chem Pharm Bull. 1985;33:5079–5082
  22. Matsuo N, Yamada K, Shoji K, Mori M, Sugano M. Effect of tea polyphenols on histamine release from rat basophilic leukemia (RBL-2H3) cells: the structure-inhibitory activity relationship. Allergy. 1997;52:58–64
  23. Kar K, Mohanta PK, Popli SP, Dhawan BN. Inhibition of passive cutaneous anaphylaxis by compounds of Camellia sinensis. Planta Medica. 1981;42:75–78
  24. Ohmori Y, Ito M, Kishi M, Mizutani H, Katada T. Antiallergic constituents from oolong tea stem. Biol Pharm Bull. 1995;18:683–686
  25. Foreman JC. Mast cells and the actions of flavonoids. J Allergy Clin Immunol. 1984;73:769–774
  26. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol. 1986;136:2348–2357
  27. Paul WE, Seder RA. Lymphokine responses and cytokines. Cell. 1994;76:241–251
  28. Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol. 1994;12:227–257
  29. Seder RA, Paul WE. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol. 1994;12:635–673
  30. Yoshimoto T, Paul WE. CD4+NK1.1+T cells promptly produce interleukin-4 in response to in vitro challenge with anti-CD3. J Exp Med. 1994;179:1285–1295
  31. Ochi H, Tanaka T, Katada Y, Naka T, Aitani M, Hashimoto S, et al.  Peripheral blood T lymphocytes and basophils, freshly isolated from house dust mite sensitive patients, produce interleukin-4 in response to allergen-specific stimulation. Int Arch Allergy Immunol. 1996;111:253–261
  32. Bradding P, Feather IH, Howarth PH, Mueller R, Roberts JA, Britten K, et al.  Interleukin 4 is localized to and released by human mast cells. J Exp Med. 1992;176:1381–1386
  33. Horsmanheimo L, Harvima IT, Jarvikallio A, Harvima RJ, Naukkarinen A, Horsmanheimo M, et al.  Mast cells are one major source of interleukin-4 in atopic dermatitis. Br J Dermatol. 1994;131:348–353

☆ Supported in part by the Ministry of Education, Science, and Culture of Japan; the Ministry of Health and Welfare of Japan; Astra Research Grant for Asthma Research; Japan Research Foundation for Clinical Pharmacology; and the Pollution-related Health Damage Compensation and Prevention Association of Japan.

☆☆ Reprint requests: Toshio Tanaka, MD, PhD, Department III of Internal Medicine, Osaka University Medical School, 2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan.

PII: S0091-6749(00)90951-5

doi: 10.1067/mai.2000.107194

The Journal of Allergy and Clinical Immunology
Volume 106, Issue 1 , Pages 159-166 , July 2000

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